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Publications - Equipe Probihôte

Articles et revues publiés de 2008 à juin 2017

Bibliographie de l’équipe ProbiHôte : articles et revues de l'année 2008 - à juin 2017

Année 2017 (juin)


Amiot, A.; Serrero, M.; Peyrin-Biroulet, L.; Filippi, J.; Pariente, B.; Roblin, X.; Buisson, A.; Stefanescu, C.; Trang-Poisson, C.; Altwegg, R.; Marteau, P.; Vaysse, T.; Bourrier, A.; Nancey, S.; Laharie, D.; Allez, M.; Savoye, G.; Moreau, J.; Vuitton, L.; Viennot, S.; Aubourg, A.; Pelletier, A. L.; Bouguen, G.; Abitbol, V.; Gagniere, C.; Bouhnik, Y.; group, O.-I. s.; the, G. One-year effectiveness and safety of vedolizumab therapy for inflammatory bowel disease: a prospective multicentre cohort study. Alimentary pharmacology & therapeutics 2017, 46 (3), 310-321.

Beaumont, M.; Jaoui, D.; Douard, V.; Mat, D.; Koeth, F.; Goustard, B.; Mayeur, C.; Mondot, S.; Hovaghimian, A.; Le Feunteun, S.; Chaumontet, C.; Davila, A. M.; Tome, D.; Souchon, I.; Michon, C.; Fromentin, G.; Blachier, F.; Leclerc, M. Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats. Molecular nutrition & food research 2017.

Breban, M.; Tap, J.; Leboime, A.; Said-Nahal, R.; Langella, P.; Chiocchia, G.; Furet, J. P.; Sokol, H. Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Annals of the rheumatic diseases 2017.

Breyner, N. M.; Michon, C.; de Sousa, C. S.; Vilas Boas, P. B.; Chain, F.; Azevedo, V. A.; Langella, P.; Chatel, J. M. Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-kappaB Pathway. Frontiers in microbiology 2017, 8, 114.

Cammarota, G.; Ianiro, G.; Tilg, H.; Rajilic-Stojanovic, M.; Kump, P.; Satokari, R.; Sokol, H.; Arkkila, P.; Pintus, C.; Hart, A.; Segal, J.; Aloi, M.; Masucci, L.; Molinaro, A.; Scaldaferri, F.; Gasbarrini, G.; Lopez-Sanroman, A.; Link, A.; de Groot, P.; de Vos, W. M.; Hogenauer, C.; Malfertheiner, P.; Mattila, E.; Milosavljevic, T.; Nieuwdorp, M.; Sanguinetti, M.; Simren, M.; Gasbarrini, A.; European, F. M. T. W. G. European consensus conference on faecal microbiota transplantation in clinical practice. Gut 2017, 66 (4), 569-580.

Carvalho, R. D.; Breyner, N.; Menezes-Garcia, Z.; Rodrigues, N. M.; Lemos, L.; Maioli, T. U.; da Gloria Souza, D.; Carmona, D.; de Faria, A. M.; Langella, P.; Chatel, J. M.; Bermudez-Humaran, L. G.; Figueiredo, H. C.; Azevedo, V.; de Azevedo, M. S. Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis. Microbial cell factories 2017, 16 (1), 27.

Carvalho, R. D. O.; do Carmo, F. L. R.; de Oliveira Junior, A.; Langella, P.; Chatel, J. M.; Bermudez-Humaran, L. G.; Azevedo, V.; de Azevedo, M. S. Use of Wild Type or Recombinant Lactic Acid Bacteria as an Alternative Treatment for Gastrointestinal Inflammatory Diseases: A Focus on Inflammatory Bowel Diseases and Mucositis. Frontiers in microbiology 2017, 8, 800.

Cherbuy, C.; Vaugelade, P.; Labarthe, S.; Honvo-Houeto, E.; Darcy-Vrillon, B.; Watford, M.; Duee, P. H. The Contribution of Intestinal Gluconeogenesis to Glucose Homeostasis Is Low in 2-Day-Old Pigs. The Journal of nutrition 2017, 147 (3), 361-366.

Chong-Nguyen, C.; Duboc, H.; Sokol, H. [The gut microbiota, a new cardiovascular risk factor?]. Presse medicale 2017.

Del Carmen, S.; de Moreno de LeBlanc, A.; Levit, R.; Azevedo, V.; Langella, P.; Bermudez-Humaran, L. G.; LeBlanc, J. G. Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. International immunopharmacology 2017, 42, 122-129.

Dunogue, B.; Pilmis, B.; Mahlaoui, N.; Elie, C.; Coignard-Biehler, H.; Amazzough, K.; Noel, N.; Salvator, H.; Catherinot, E.; Couderc, L. J.; Sokol, H.; Lanternier, F.; Fouyssac, F.; Bardet, J.; Bustamante, J.; Gougerot-Pocidalo, M. A.; Barlogis, V.; Masseau, A.; Durieu, I.; Lecuit, M.; Suarez, F.; Fischer, A.; Blanche, S.; Hermine, O.; Lortholary, O. Chronic Granulomatous Disease in Patients Reaching Adulthood: A Nationwide Study in France. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64 (6), 767-775.

Ferrere, G.; Wrzosek, L.; Cailleux, F.; Turpin, W.; Puchois, V.; Spatz, M.; Ciocan, D.; Rainteau, D.; Humbert, L.; Hugot, C.; Gaudin, F.; Noordine, M. L.; Robert, V.; Berrebi, D.; Thomas, M.; Naveau, S.; Perlemuter, G.; Cassard, A. M. Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice. Journal of hepatology 2017, 66 (4), 806-815.

Fumery, M.; Seksik, P.; Auzolle, C.; Munoz-Bongrand, N.; Gornet, J. M.; Boschetti, G.; Cotte, E.; Buisson, A.; Dubois, A.; Pariente, B.; Zerbib, P.; Chafai, N.; Stefanescu, C.; Panis, Y.; Marteau, P.; Pautrat, K.; Sabbagh, C.; Filippi, J.; Chevrier, M.; Houze, P.; Jouven, X.; Treton, X.; Allez, M.; investigators, R. s. g. Postoperative Complications after Ileocecal Resection in Crohn's Disease: A Prospective Study From the REMIND Group. The American journal of gastroenterology 2017, 112 (2), 337-345.

Galperine, T.; Sokol, H.; Guery, B. Fecal Microbiota Transplantation: Do We Need Harmonization? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64 (9), 1292.

Gillard, L.; Mayeur, C.; Robert, V.; Pingenot, I.; Le Beyec, J.; Bado, A.; Lepage, P.; Thomas, M.; Joly, F. Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome. Frontiers in physiology 2017, 8, 224.

Hacini-Rachinel, F.; Gomez de Aguero, M.; Kanjarawi, R.; Moro-Sibilot, L.; Le Luduec, J. B.; Macari, C.; Boschetti, G.; Bardel, E.; Langella, P.; Dubois, B.; Kaiserlian, D. Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis. The Journal of allergy and clinical immunology 2017.

Lamas, B.; Richard, M. L.; Sokol, H. Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases. Current opinion in clinical nutrition and metabolic care 2017, 20 (4), 243-247.

LeBlanc, J. G.; Chain, F.; Martin, R.; Bermudez-Humaran, L. G.; Courau, S.; Langella, P. Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria. Microbial cell factories 2017, 16 (1), 79.

Mancha-Agresti, P.; Drumond, M. M.; Carmo, F. L.; Santos, M. M.; Santos, J. S.; Venanzi, F.; Chatel, J. M.; Leclercq, S. Y.; Azevedo, V. A New Broad Range Plasmid for DNA Delivery in Eukaryotic Cells Using Lactic Acid Bacteria: In Vitro and In Vivo Assays. Molecular therapy. Methods & clinical development 2017, 4, 83-91.

Mariat, D.; Robert, V.; Langella, P.; Chatel, J. M. Plasmid transfer efficiency using Lactoccocus lactis strains depends on invasiveness status but also on plasmid copy number. FEMS microbiology letters 2017.

Martin, R.; Miquel, S.; Benevides, L.; Bridonneau, C.; Robert, V.; Hudault, S.; Chain, F.; Berteau, O.; Azevedo, V.; Chatel, J. M.; Sokol, H.; Bermudez-Humaran, L. G.; Thomas, M.; Langella, P. Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic. Frontiers in microbiology 2017, 8, 1226.

Mathieu, E.; Bernard, A. S.; Delsuc, N.; Quevrain, E.; Gazzah, G.; Lai, B.; Chain, F.; Langella, P.; Bachelet, M.; Masliah, J.; Seksik, P.; Policar, C. A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic Is Able To Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases. Inorganic chemistry 2017, 56 (5), 2545-2555.

Pascal, V.; Pozuelo, M.; Borruel, N.; Casellas, F.; Campos, D.; Santiago, A.; Martinez, X.; Varela, E.; Sarrabayrouse, G.; Machiels, K.; Vermeire, S.; Sokol, H.; Guarner, F.; Manichanh, C. A microbial signature for Crohn's disease. Gut 2017, 66 (5), 813-822.

Radziwill-Bienkowska, J. M.; Robert, V.; Drabot, K.; Chain, F.; Cherbuy, C.; Langella, P.; Thomas, M.; Bardowski, J. K.; Mercier-Bonin, M.; Kowalczyk, M. Contribution of plasmid-encoded peptidase S8 (PrtP) to adhesion and transit in the gut of Lactococcus lactis IBB477 strain. Applied microbiology and biotechnology 2017, 101 (14), 5709-5721.

Remot, A.; Descamps, D.; Noordine, M. L.; Boukadiri, A.; Mathieu, E.; Robert, V.; Riffault, S.; Lambrecht, B.; Langella, P.; Hammad, H.; Thomas, M. Bacteria isolated from lung modulate asthma susceptibility in mice. The ISME journal 2017, 11 (5), 1061-1074.

Sokol, H.; Adolph, T. E. The microbiota: an underestimated actor in radiation-induced lesions? Gut 2017.

Sokol, H.; Lalande, V.; Landman, C.; Bourrier, A.; Nion-Larmurier, I.; Rajca, S.; Kirchgesner, J.; Seksik, P.; Cosnes, J.; Barbut, F.; Beaugerie, L. Clostridium difficile infection in acute flares of inflammatory bowel disease: A prospective study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2017, 49 (6), 643-646.

Sokol, H.; Leducq, V.; Aschard, H.; Pham, H. P.; Jegou, S.; Landman, C.; Cohen, D.; Liguori, G.; Bourrier, A.; Nion-Larmurier, I.; Cosnes, J.; Seksik, P.; Langella, P.; Skurnik, D.; Richard, M. L.; Beaugerie, L. Fungal microbiota dysbiosis in IBD. Gut 2017, 66 (6), 1039-1048.

Souza, R. F.; Jardin, J.; Cauty, C.; Rault, L.; Bouchard, D. S.; Bermudez-Humaran, L. G.; Langella, P.; Monedero, V.; Seyffert, N.; Azevedo, V.; Le Loir, Y.; Even, S. Contribution of sortase SrtA2 to Lactobacillus casei BL23 inhibition of Staphylococcus aureus internalization into bovine mammary epithelial cells. PloS one 2017, 12 (3), e0174060.


 Année 2016 

Allain, T.; Mansour, N. M.; Bahr, M. M.; Martin, R.; Florent, I.; Langella, P.; Bermudez-Humaran, L. G. A new lactobacilli in vivo expression system for the production and delivery of heterologous proteins at mucosal surfaces. FEMS microbiology letters 2016, 363 (13).

Almeida, J. F.; Breyner, N. M.; Mahi, M.; Ahmed, B.; Benbouziane, B.; Boas, P. C.; Miyoshi, A.; Azevedo, V.; Langella, P.; Bermudez-Humaran, L. G.; Chatel, J. M. Expression of fibronectin binding protein A (FnBPA) from Staphylococcus aureus at the cell surface of Lactococcus lactis improves its immunomodulatory properties when used as protein delivery vector. Vaccine 2016, 34 (10), 1312-8.

Coppo, P.; Fabiani, B.; Marzac, C.; Sokol, H. Mature CD8+ T-cell clonal expansion in the oral cavity and digestive tract: a severe lymphoid malignancy that mimics Crohn's disease. Clinical case reports 2016, 4 (12), 1088-1090.

Cosnes, J.; Sokol, H.; Bourrier, A.; Nion-Larmurier, I.; Wisniewski, A.; Landman, C.; Marteau, P.; Beaugerie, L.; Perez, K.; Seksik, P. Adalimumab or infliximab as monotherapy, or in combination with an immunomodulator, in the treatment of Crohn's disease. Alimentary pharmacology & therapeutics 2016, 44 (10), 1102-1113.

Daillere, R.; Vetizou, M.; Waldschmitt, N.; Yamazaki, T.; Isnard, C.; Poirier-Colame, V.; Duong, C. P.; Flament, C.; Lepage, P.; Roberti, M. P.; Routy, B.; Jacquelot, N.; Apetoh, L.; Becharef, S.; Rusakiewicz, S.; Langella, P.; Sokol, H.; Kroemer, G.; Enot, D.; Roux, A.; Eggermont, A.; Tartour, E.; Johannes, L.; Woerther, P. L.; Chachaty, E.; Soria, J. C.; Golden, E.; Formenti, S.; Plebanski, M.; Madondo, M.; Rosenstiel, P.; Raoult, D.; Cattoir, V.; Boneca, I. G.; Chamaillard, M.; Zitvogel, L. Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity 2016, 45 (4), 931-943.

de Moreno de LeBlanc, A.; Del Carmen, S.; Chatel, J. M.; Azevedo, V.; Langella, P.; Bermudez-Humaran, L.; LeBlanc, J. G. Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis. Journal of medical microbiology 2016, 65 (9), 1038-46.

De Paepe, M.; Tournier, L.; Moncaut, E.; Son, O.; Langella, P.; Petit, M. A. Carriage of lambda Latent Virus Is Costly for Its Bacterial Host due to Frequent Reactivation in Monoxenic Mouse Intestine. PLoS genetics 2016, 12 (2), e1005861.

Del Carmen, S.; de Moreno de LeBlanc, A.; Levit, R.; Azevedo, V.; Langella, P.; Bermudez-Humaran, L. G.; LeBlanc, J. G. Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. International immunopharmacology 2016, 42, 122-129.

Deschemin, J. C.; Noordine, M. L.; Remot, A.; Willemetz, A.; Afif, C.; Canonne-Hergaux, F.; Langella, P.; Karim, Z.; Vaulont, S.; Thomas, M.; Nicolas, G. The microbiota shifts the iron sensing of intestinal cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016, 30 (1), 252-61.

Dior, M.; Delagreverie, H.; Duboc, H.; Jouet, P.; Coffin, B.; Brot, L.; Humbert, L.; Trugnan, G.; Seksik, P.; Sokol, H.; Rainteau, D.; Sabate, J. M. Interplay between bile acid metabolism and microbiota in irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2016, 28 (9), 1330-40.

Fischer, M.; Kao, D.; Kelly, C.; Kuchipudi, A.; Jafri, S. M.; Blumenkehl, M.; Rex, D.; Mellow, M.; Kaur, N.; Sokol, H.; Cook, G.; Hamilton, M. J.; Phelps, E.; Sipe, B.; Xu, H.; Allegretti, J. R. Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease. Inflammatory bowel diseases 2016, 22 (10), 2402-9.

Georgin-Lavialle, S.; Launay, J. M.; Cote, F.; Soucie, E.; Soria, A.; Damaj, G.; Moura, D. S.; Canioni, D.; Hanssens, K.; Chandesris, M. O.; Barete, S.; Dubreuil, P.; Lortholary, O.; Hermine, O.; Sokol, H. Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms. Allergy 2016, 71 (3), 416-20.

Gillard, L.; Billiauws, L.; Stan-Iuga, B.; Ribeiro-Parenti, L.; Jarry, A. C.; Cavin, J. B.; Cluzeaud, F.; Mayeur, C.; Thomas, M.; Freund, J. N.; Lacorte, J. M.; Le Gall, M.; Bado, A.; Joly, F.; Le Beyec, J. Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome. Scientific reports 2016, 6, 28345.

Hoffmann, T. W.; Pham, H. P.; Bridonneau, C.; Aubry, C.; Lamas, B.; Martin-Gallausiaux, C.; Moroldo, M.; Rainteau, D.; Lapaque, N.; Six, A.; Richard, M. L.; Fargier, E.; Le Guern, M. E.; Langella, P.; Sokol, H. Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice. The ISME journal 2016, 10 (2), 460-77.

Kirchgesner, J.; Sokol, H. Editorial: mongersen in Crohn's disease--a new contribution to the beginning of a long-awaited therapeutic revolution? Alimentary pharmacology & therapeutics 2016, 43 (7), 838-9.

Lamas, B.; Richard, M. L.; Leducq, V.; Pham, H. P.; Michel, M. L.; Da Costa, G.; Bridonneau, C.; Jegou, S.; Hoffmann, T. W.; Natividad, J. M.; Brot, L.; Taleb, S.; Couturier-Maillard, A.; Nion-Larmurier, I.; Merabtene, F.; Seksik, P.; Bourrier, A.; Cosnes, J.; Ryffel, B.; Beaugerie, L.; Launay, J. M.; Langella, P.; Xavier, R. J.; Sokol, H. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nature medicine 2016, 22 (6), 598-605.

Lenoir, M.; Del Carmen, S.; Cortes-Perez, N. G.; Lozano-Ojalvo, D.; Munoz-Provencio, D.; Chain, F.; Langella, P.; de Moreno de LeBlanc, A.; LeBlanc, J. G.; Bermudez-Humaran, L. G. Lactobacillus casei BL23 regulates Treg and Th17 T-cell populations and reduces DMH-associated colorectal cancer. Journal of gastroenterology 2016, 51 (9), 862-73.

Leonard, L.; Husson, F.; Langella, P.; Chatel, J. M.; Saurel, R. Aqueous two-phase system cold-set gelation using natural and recombinant probiotic lactic acid bacteria as a gelling agent. Colloids and surfaces. B, Biointerfaces 2016, 141, 338-44.

Liguori, G.; Lamas, B.; Richard, M. L.; Brandi, G.; da Costa, G.; Hoffmann, T. W.; Di Simone, M. P.; Calabrese, C.; Poggioli, G.; Langella, P.; Campieri, M.; Sokol, H. Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn's Disease Patients. Journal of Crohn's & colitis 2016, 10 (3), 296-305.

Martin, R.; Bermudez-Humaran, L. G.; Langella, P. Gnotobiotic Rodents: An In Vivo Model for the Study of Microbe-Microbe Interactions. Frontiers in microbiology 2016, 7, 409.

Martin, R.; Laval, L.; Chain, F.; Miquel, S.; Natividad, J.; Cherbuy, C.; Sokol, H.; Verdu, E. F.; van Hylckama Vlieg, J.; Bermudez-Humaran, L. G.; Smokvina, T.; Langella, P. Bifidobacterium animalis ssp. lactis CNCM-I2494 Restores Gut Barrier Permeability in Chronically Low-Grade Inflamed Mice. Frontiers in microbiology 2016, 7, 608.

Mayeur, C.; Gillard, L.; Le Beyec, J.; Bado, A.; Joly, F.; Thomas, M. Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome. Microorganisms 2016, 4 (1).

Mayorga Reyes, L.; Gonzalez Vazquez, R.; Cruz Arroyo, S. M.; Melendez Avalos, A.; Reyes Castillo, P. A.; Chavaro Perez, D. A.; Ramos Terrones, I.; Ramos Ibanez, N.; Rodriguez Magallanes, M. M.; Langella, P.; Bermudez Humaran, L.; Azaola Espinosa, A. Correlation between diet and gut bacteria in a population of young adults. International journal of food sciences and nutrition 2016, 67 (4), 470-8.

Mercier-Bonin, M.; Despax, B.; Raynaud, P.; Houdeau, E.; Thomas, M. Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Critical reviews in food science and nutrition 2016, 1-10.

Michon, C.; Langella, P.; Eijsink, V. G.; Mathiesen, G.; Chatel, J. M. Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications. Microbial cell factories 2016, 15, 70.

Miquel, S.; Martin, R.; Lashermes, A.; Gillet, M.; Meleine, M.; Gelot, A.; Eschalier, A.; Ardid, D.; Bermudez-Humaran, L. G.; Sokol, H.; Thomas, M.; Theodorou, V.; Langella, P.; Carvalho, F. A. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models. Scientific reports 2016, 6, 19399.

Pigneur, B.; Sokol, H. Fecal microbiota transplantation in inflammatory bowel disease: the quest for the holy grail. Mucosal immunology 2016, 9 (6), 1360-1365.

Quevrain, E.; Maubert, M. A.; Michon, C.; Chain, F.; Marquant, R.; Tailhades, J.; Miquel, S.; Carlier, L.; Bermudez-Humaran, L. G.; Pigneur, B.; Lequin, O.; Kharrat, P.; Thomas, G.; Rainteau, D.; Aubry, C.; Breyner, N.; Afonso, C.; Lavielle, S.; Grill, J. P.; Chassaing, G.; Chatel, J. M.; Trugnan, G.; Xavier, R.; Langella, P.; Sokol, H.; Seksik, P. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. Gut 2016, 65 (3), 415-25.

Quevrain, E.; Maubert, M. A.; Sokol, H.; Devreese, B.; Seksik, P. The presence of the anti-inflammatory protein MAM, from Faecalibacterium prausnitzii, in the intestinal ecosystem. Gut 2016, 65 (5), 882.

Reygner, J.; Joly Condette, C.; Bruneau, A.; Delanaud, S.; Rhazi, L.; Depeint, F.; Abdennebi-Najar, L.; Bach, V.; Mayeur, C.; Khorsi-Cauet, H. Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME(R) Model. International journal of environmental research and public health 2016, 13 (11).

Rossi, O.; van Berkel, L. A.; Chain, F.; Tanweer Khan, M.; Taverne, N.; Sokol, H.; Duncan, S. H.; Flint, H. J.; Harmsen, H. J.; Langella, P.; Samsom, J. N.; Wells, J. M. Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses. Scientific reports 2016, 6, 18507.

Sokol, H. Toward Rational Donor Selection in Faecal Microbiota Transplantation for IBD. Journal of Crohn's & colitis 2016, 10 (4), 375-6.

Sokol, H.; Galperine, T.; Kapel, N.; Bourlioux, P.; Seksik, P.; Barbut, F.; Scanzi, J.; Chast, F.; Batista, R.; Joly, F.; et al.,  F. Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2016, 48 (3), 242-7.

Sokol, H.; Leducq, V.; Aschard, H.; Pham, H. P.; Jegou, S.; Landman, C.; Cohen, D.; Liguori, G.; Bourrier, A.; Nion-Larmurier, I.; Cosnes, J.; Seksik, P.; Langella, P.; Skurnik, D.; Richard, M. L.; Beaugerie, L. Fungal microbiota dysbiosis in IBD. Gut 2016.

Souza, B. M.; Preisser, T. M.; Pereira, V. B.; Zurita-Turk, M.; de Castro, C. P.; da Cunha, V. P.; de Oliveira, R. P.; Gomes-Santos, A. C.; de Faria, A. M.; Machado, D. C.; Chatel, J. M.; Azevedo, V. A.; Langella, P.; Miyoshi, A. Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells. Microbial cell factories 2016, 15 (1), 150.

Torres-Maravilla, E.; Lenoir, M.; Mayorga-Reyes, L.; Allain, T.; Sokol, H.; Langella, P.; Sanchez-Pardo, M. E.; Bermudez-Humaran, L. G. Identification of novel anti-inflammatory probiotic strains isolated from pulque. Applied microbiology and biotechnology 2016, 100 (1), 385-396.


Aubry, C.; Michon, C.; Chain, F.; Chvatchenko, Y.; Goffin, L.; Zimmerli, S. C.; Leguin, S.; Langella, P.; Bermudez-Humaran, L.; Chatel, J. M. Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model. Microb Cell Fact 2015,14 (1), 176.

Bejaoui, M.; Sokol, H.; Marteau, P. Targeting the Microbiome in Inflammatory Bowel Disease: Critical Evaluation of Current Concepts and Moving to New Horizons. Dig Dis 2015,33 Suppl 1, 105-112.

Bermudez-Humaran, L. G.; Motta, J. P.; Aubry, C.; Kharrat, P.; Rous-Martin, L.; Sallenave, J. M.; Deraison, C.; Vergnolle, N.; Langella, P. Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci. Microb Cell Fact 2015,14, 26.

Bouchard, D. S.; Seridan, B.; Saraoui, T.; Rault, L.; Germon, P.; Gonzalez-Moreno, C.; Nader-Macias, F. M.; Baud, D.; Francois, P.; Chuat, V., et al. Lactic Acid Bacteria Isolated from Bovine Mammary Microbiota: Potential Allies against Bovine Mastitis. PLoS One 2015,10 (12), e0144831.

Boussen, I.; Sokol, H.; Aractingi, S.; Georges, O.; Hoyeau-Idrissi, N.; Hugot, J. P.; Mohty, M.; Rubio, M. T. Inflammatory bowel disease after allogeneic stem cell transplantation. Bone Marrow Transplant 2015,50 (10), 1365-6.

Cortes-Perez, N. G.; Dumoulin, R.; Gaubert, S.; Lacoux, C.; Bugli, F.; Martin, R.; Chat, S.; Piquand, K.; Meylheuc, T.; Langella, P., et al. Overexpression of Enterococcus faecalis elr operon protects from phagocytosis. BMC Microbiol 2015,15, 112.

de Azevedo, M.; Meijerink, M.; Taverne, N.; Pereira, V. B.; LeBlanc, J. G.; Azevedo, V.; Miyoshi, A.; Langella, P.; Wells, J. M.; Chatel, J. M. Recombinant invasive Lactococcus lactis can transfer DNA vaccines either directly to dendritic cells or across an epithelial cell monolayer. Vaccine 2015,33 (38), 4807-12.

de Moreno de LeBlanc, A.; Del Carmen, S.; Chatel, J. M.; Miyoshi, A.; Azevedo, V.; Langella, P.; Bermudez-Humaran, L. G.; LeBlanc, J. G. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterol Res Pract 2015,2015, 146972.

Gagniere, C.; Beaugerie, L.; Pariente, B.; Seksik, P.; Amiot, A.; Abitbol, V.; Allez, M.; Cosnes, J.; Sokol, H. Benefit of infliximab reintroduction after successive failure of infliximab and adalimumab in Crohn's disease. Journal of Crohn's & colitis 2015,9 (4), 349-55.

Gilletta, C.; Lewin, M.; Bourrier, A.; Nion-Larmurier, I.; Rajca, S.; Beaugerie, L.; Sokol, H.; Pariente, B.; Seksik, P.; Cosnes, J. Changes in the Lemann Index Values During the First Years of Crohn's Disease. Clin Gastroenterol Hepatol 2015,13 (9), 1633-40 e3.

Iaconelli, C.; Lemetais, G.; Kechaou, N.; Chain, F.; Bermudez-Humaran, L. G.; Langella, P.; Gervais, P.; Beney, L. Drying process strongly affects probiotics viability and functionalities. J Biotechnol 2015,214, 17-26.

Joly Condette, C.; Bach, V.; Mayeur, C.; Gay-Queheillard, J.; Khorsi-Cauet, H. Chlorpyrifos Exposure During Perinatal Period Affects Intestinal Microbiota Associated With Delay of Maturation of Digestive Tract in Rats. J Pediatr Gastroenterol Nutr 2015,61 (1), 30-40.

Juillerat, P.; Sokol, H.; Froehlich, F.; Yajnik, V.; Beaugerie, L.; Lucci, M.; Burnand, B.; Macpherson, A. J.; Cosnes, J.; Korzenik, J. R. Factors associated with durable response to infliximab in Crohn's disease 5 years and beyond: a multicenter international cohort. Inflamm Bowel Dis 2015,21 (1), 60-70.

Laval, L.; Martin, R.; Natividad, J. N.; Chain, F.; Miquel, S.; Desclee de Maredsous, C.; Capronnier, S.; Sokol, H.; Verdu, E. F.; van Hylckama Vlieg, J. E., et al. Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice. Gut Microbes 2015,6 (1), 1-9.

Liguori, G.; Lamas, B.; Richard, M. L.; Brandi, G.; da Costa, G.; Hoffmann, T. W.; Di Simone, M. P.; Calabrese, C.; Poggioli, G.; Langella, P., et al. Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn's Disease Patients. Journal of Crohn's & colitis 2015.

Martin, R.; Miquel, S.; Chain, F.; Natividad, J. M.; Jury, J.; Lu, J.; Sokol, H.; Theodorou, V.; Bercik, P.; Verdu, E. F., et al. Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol 2015,15, 67.

Martin, R.; Sanchez, B.; Urdaci, M. C.; Langella, P.; Suarez, J. E.; Bermudez-Humaran, L. G. Effect of iron on the probiotic properties of the vaginal isolate Lactobacillus jensenii CECT 4306. Microbiology 2015,161 (Pt 4), 708-18.

Michon, C.; Kuczkowska, K.; Langella, P.; Eijsink, V. G.; Mathiesen, G.; Chatel, J. M. Surface display of an anti-DEC-205 single chain Fv fragment in Lactobacillus plantarum increases internalization and plasmid transfer to dendritic cells in vitro and in vivo. Microb Cell Fact 2015,14, 95.

Miquel, S.; Beaumont, M.; Martin, R.; Langella, P.; Braesco, V.; Thomas, M. A proposed framework for an appropriate evaluation scheme for microorganisms as novel foods with a health claim in Europe. Microb Cell Fact 2015,14, 48.

Miquel, S.; Leclerc, M.; Martin, R.; Chain, F.; Lenoir, M.; Raguideau, S.; Hudault, S.; Bridonneau, C.; Northen, T.; Bowen, B., et al. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii. MBio 2015,6 (2).

Quevrain, E.; Maubert, M. A.; Michon, C.; Chain, F.; Marquant, R.; Tailhades, J.; Miquel, S.; Carlier, L.; Bermudez-Humaran, L. G.; Pigneur, B., et al. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. Gut 2015.

Rhimi, M.; Bermudez-Humaran, L. G.; Huang, Y.; Boudebbouze, S.; Gaci, N.; Garnier, A.; Gratadoux, J. J.; Mkaouar, H.; Langella, P.; Maguin, E. The secreted L-arabinose isomerase displays anti-hyperglycemic effects in mice. Microb Cell Fact 2015,14 (1), 204.

Richard, M. L.; Lamas, B.; Liguori, G.; Hoffmann, T. W.; Sokol, H. Gut fungal microbiota: the Yin and Yang of inflammatory bowel disease. Inflamm Bowel Dis 2015,21 (3), 656-65.

Saraiva, T. D.; Morais, K.; Pereira, V. B.; de Azevedo, M.; Rocha, C. S.; Prosperi, C. C.; Gomes-Santos, A. C.; Bermudez-Humaran, L.; Faria, A. M.; Blottiere, H. M., et al. Milk fermented with a 15-lipoxygenase-1-producing Lactococcus lactis alleviates symptoms of colitis in a murine model. Curr Pharm Biotechnol 2015,16 (5), 424-9.

Sokol, H.; Galperine, T.; Kapel, N.; Bourlioux, P.; Seksik, P.; Barbut, F.; Scanzi, J.; Chast, F.; Batista, R.; Joly, F., et al. Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2015.

Syer, S. D.; Blackler, R. W.; Martin, R.; de Palma, G.; Rossi, L.; Verdu, E.; Bercik, P.; Surette, M. G.; Aucouturier, A.; Langella, P., et al. NSAID enteropathy and bacteria: a complicated relationship. Journal of gastroenterology 2015,50 (4), 387-93.

Thomas, M.; Langella, P.; Neyrolles, O. [Lactobacillus acidophilus: a promising tool for the treatment of inflammatory bowel diseases?]. Med Sci (Paris) 2015,31 (8-9), 715-7.

Tomas, J.; Reygner, J.; Mayeur, C.; Ducroc, R.; Bouet, S.; Bridonneau, C.; Cavin, J. B.; Thomas, M.; Langella, P.; Cherbuy, C. Early colonizing Escherichia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state. ISME J 2015,9 (1), 46-58.

Torres-Maravilla, E.; Lenoir, M.; Mayorga-Reyes, L.; Allain, T.; Sokol, H.; Langella, P.; Sanchez-Pardo, M. E.; Bermudez-Humaran, L. G. Identification of novel anti-inflammatory probiotic strains isolated from pulque. Applied microbiology and biotechnology 2015.

Viaud, S.; Daillere, R.; Boneca, I. G.; Lepage, P.; Langella, P.; Chamaillard, M.; Pittet, M. J.; Ghiringhelli, F.; Trinchieri, G.; Goldszmid, R., et al. Gut microbiome and anticancer immune response: really hot Sh*t! Cell Death Differ 2015,22 (2), 199-214.

Wu, C. Y.; Bermudez-Humaran, L. G.; Yue, F.; Li, M.; Zhang, L. P. Intranasal administration with recombinant Lactococcus lactis expressing heme oxygenase-1 reduces hyperoxia-induced lung inflammation in rat pups. Biotechnol Lett 2015,37 (6), 1203-11.


Almeida JF, Mariat D, Azevedo V, Miyoshi A, de Moreno de LeBlanc A, Del Carmen S, Martin R, Langella P, LeBlanc JG, Chatel JM: Correlation between fibronectin binding protein A expression level at the surface of recombinant lactococcus lactis and plasmid transfer in vitro and in vivo. BMC Microbiol 2014, 14(1):248.

Barret M, de Parades V, Battistella M, Sokol H, Lemarchand N, Marteau P: Crohn's disease of the vulva. J Crohns Colitis 2014, 8(7):563-570.

Beaugerie L, Carrat F, Colombel JF, Bouvier AM, Sokol H, Babouri A, Carbonnel F, Laharie D, Faucheron JL, Simon T et al: Risk of new or recurrent cancer under immunosuppressive therapy in patients with IBD and previous cancer. Gut 2014, 63(9):1416-1423.

Del Carmen S, de Moreno de LeBlanc A, Martin R, Chain F, Langella P, Bermudez-Humaran LG, LeBlanc JG: Genetically engineered immunomodulatory Streptococcus thermophilus strains producing antioxidant enzymes exhibit enhanced anti-inflammatory activities. Appl Environ Microbiol 2014, 80(3):869-877.

del Carmen S, Martin Rosique R, Saraiva T, Zurita-Turk M, Miyoshi A, Azevedo V, de Moreno de LeBlanc A, Langella P, Bermudez-Humaran LG, LeBlanc JG: Protective effects of lactococci strains delivering either IL-10 protein or cDNA in a TNBS-induced chronic colitis model. J Clin Gastroenterol 2014, 48 Suppl 1:S12-17.

Delvincourt M, Lopez A, Pillet S, Bourrier A, Seksik P, Cosnes J, Carrat F, Gozlan J, Beaugerie L, Roblin X et al: The impact of cytomegalovirus reactivation and its treatment on the course of inflammatory bowel disease. Aliment Pharmacol Ther 2014, 39(7):712-720.

Delvincourt M, Sokol H: Letter: not the end of the role of anti-viral therapy in ulcerative colitis with cytomegalovirus reactivation - authors' reply. Aliment Pharmacol Ther 2014, 39(10):1247-1248.

Ebel B, Lemetais G, Beney L, Cachon R, Sokol H, Langella P, Gervais P: Impact of probiotics on risk factors for cardiovascular diseases. A review. Crit Rev Food Sci Nutr 2014, 54(2):175-189.

Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R et al: Novel role of the serine protease inhibitor elafin in gluten-related disorders. Am J Gastroenterol 2014, 109(5):748-756.

Hayes CL, Natividad JM, Jury J, Martin R, Langella P, Verdu EF: Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration. Benef Microbes 2014, 5(1):79-88.

Juste C, Kreil DP, Beauvallet C, Guillot A, Vaca S, Carapito C, Mondot S, Sykacek P, Sokol H, Blon F et al: Bacterial protein signals are associated with Crohn's disease. Gut 2014, 63(10):1566-1577.

Kapel N, Thomas M, Corcos O, Mayeur C, Barbot-Trystram L, Bouhnik Y, Joly F: Practical implementation of faecal transplantation. Clin Microbiol Infect 2014, 20(11):1098-1105.

Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS et al: Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nat Commun 2014, 5:4675.

Laval L, Martin R, Natividad J, Chain F, Miquel S, de Maredsous CD, Capronnier S, Sokol H, Verdu E, van Hylckama Vlieg J et al: Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice. Gut Microbes 2014:1-9.

Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ: An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS One 2014, 9(9):e108777.

Magro F, Peyrin-Biroulet L, Sokol H, Aldeger X, Costa A, Higgins PD, Joyce JC, Katsanos KH, Lopez A, de Xaxars TM et al: Extra-intestinal malignancies in inflammatory bowel disease: results of the 3rd ECCO Pathogenesis Scientific Workshop (III). J Crohns Colitis 2014, 8(1):31-44.

Martin R, Chain F, Miquel S, Lu J, Gratadoux JJ, Sokol H, Verdu EF, Bercik P, Bermudez-Humaran LG, Langella P: The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models. Inflamm Bowel Dis 2014, 20(3):417-430.

Martin R, Chain F, Miquel S, Natividad JM, Sokol H, Verdu EF, Langella P, Bermudez-Humaran LG: Effects in the use of a genetically engineered strain of Lactococcus lactis delivering in situ IL-10 as a therapy to treat low-grade colon inflammation. Hum Vaccin Immunother 2014, 10(6).

Martin R, Lenoir M, Chain F, Langella P, Bermudez-Humaran LG: The dual role of MAPK pathway in the regulation of intestinal barrier: the role of the commensal bacterium Faecalibacterium prausnitzii on this regulation. Inflamm Bowel Dis 2014, 20(7):E17-18.

Martin R, Miquel S, Langella P, Bermudez-Humaran LG: The role of metagenomics in understanding the human microbiome in health and disease. Virulence 2014, 5(3):413-423.

Martin R, Miquel S, Ulmer J, Langella P, Bermudez-Humaran LG: Gut ecosystem: how microbes help us. Benef Microbes 2014:1-15.

Miquel S, Martin R, Bridonneau C, Robert V, Sokol H, Bermudez-Humaran LG, Thomas M, Langella P: Ecology and metabolism of the beneficial intestinal commensal bacterium. Gut Microbes 2014, 5(2):146-151.

Pontes D, Azevedo M, Innocentin S, Blugeon S, Lefevre F, Azevedo V, Miyoshi A, Courtin P, Chapot-Chartier MP, Langella P et al: Immune response elicited by DNA vaccination using Lactococcus lactis is modified by the production of surface exposed pathogenic protein. PLoS One 2014, 9(1):e84509.

Rajca S, Grondin V, Louis E, Vernier-Massouille G, Grimaud JC, Bouhnik Y, Laharie D, Dupas JL, Pillant H, Picon L et al: Alterations in the intestinal microbiome (dysbiosis) as a predictor of relapse after infliximab withdrawal in Crohn's disease. Inflamm Bowel Dis 2014, 20(6):978-986.

Rajca S, Seksik P, Bourrier A, Sokol H, Nion-Larmurier I, Beaugerie L, Cosnes J: Impact of the diagnosis and treatment of cancer on the course of inflammatory bowel disease. J Crohns Colitis 2014, 8(8):819-824.

Regnault H, Bourrier A, Lalande V, Nion-Larmurier I, Sokol H, Seksik P, Barbut F, Cosnes J, Beaugerie L: Prevalence and risk factors of Clostridium difficile infection in patients hospitalized for flare of inflammatory bowel disease: a retrospective assessment. Dig Liver Dis 2014, 46(12):1086-1092.

Richard ML, Lamas B, Liguori G, Hoffmann TW, Sokol H: Gut Fungal Microbiota: The Yin and Yang of Inflammatory Bowel Disease. Inflamm Bowel Dis 2014, 2014.

Santos Rocha C, Gomes-Santos AC, Garcias Moreira T, de Azevedo M, Diniz Luerce T, Mariadassou M, Longaray Delamare AP, Langella P, Maguin E, Azevedo V et al: Local and systemic immune mechanisms underlying the anti-colitis effects of the dairy bacterium Lactobacillus delbrueckii. PLoS One 2014, 9(1):e85923.

Saraiva TD, Morais K, Pereira VB, de Azevedo M, Rocha CS, Prosperi CC, Gomes-Santos AC, Bermudez-Humaran L, Faria AM, Blottiere HM et al: Milk Fermented with a 15-Lipoxygenase-1-Producing Alleviates Symptoms of colitis in a Murine Model. Curr Pharm Biotechnol 2014.

Sarrabayrouse G, Bossard C, Chauvin JM, Jarry A, Meurette G, Quevrain E, Bridonneau C, Preisser L, Asehnoune K, Labarriere N et al: CD4CD8alphaalpha lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. PLoS Biol 2014, 12(4):e1001833.

Sokol H: Probiotics and Antibiotics in IBD. Dig Dis 2014, 32 Suppl 1:10-17.

Sokol H, Langella P: Beneficial Effects of Exclusive Enteral Nutrition in Crohn's Disease Are not Mediated by Faecalibacterium prausnitzii. Inflamm Bowel Dis 2014, 20(7):E18.

Sokol H, Seksik P, Cosnes J: Complications and surgery in the inflammatory bowel diseases biological era. Curr Opin Gastroenterol 2014, 30(4):378-384.

Zurita-Turk M, Del Carmen S, Santos AC, Pereira VB, Cara DC, Leclercq SY, de LeBlanc A, Azevedo V, Chatel JM, LeBlanc JG et al: Lactococcus lactis carrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis. BMC Biotechnol 2014, 14:73.


Archambaud C, Langella P, Lecuit M, Cossart P: Reply to Million et al.: Lactobacilli and listeriosis. Proc Natl Acad Sci U S A 2013, 110(1):E2.

Bakhtiar SM, LeBlanc JG, Salvucci E, Ali A, Martin R, Langella P, Chatel JM, Miyoshi A, Bermudez-Humaran LG, Azevedo V: Implications of the human microbiome in inflammatory bowel diseases. FEMS Microbiol Lett 2013, 342(1):10-17.

Benbouziane B, Ribelles P, Aubry C, Martin R, Kharrat P, Riazi A, Langella P, Bermudez-Humaran LG: Development of a Stress-Inducible Controlled Expression (SICE) system in Lactococcus lactis for the production and delivery of therapeutic molecules at mucosal surfaces. J Biotechnol 2013, 168(2):120-129.

Bermudez-Humaran LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P: Engineering lactococci and lactobacilli for human health. Curr Opin Microbiol 2013, 16(3):278-283.

de Azevedo MS, Innocentin S, Dorella FA, Rocha CS, Mariat D, Pontes DS, Miyoshi A, Azevedo V, Langella P, Chatel JM: Immunotherapy of allergic diseases using probiotics or recombinant probiotics. J Appl Microbiol 2013, 115(2):319-333.

Derre-Bobillot A, Cortes-Perez NG, Yamamoto Y, Kharrat P, Couve E, Da Cunha V, Decker P, Boissier MC, Escartin F, Cesselin B et al: Nuclease A (Gbs0661), an extracellular nuclease of Streptococcus agalactiae, attacks the neutrophil extracellular traps and is needed for full virulence. Mol Microbiol 2013, 89(3):518-531.

Duboc H, Rajca S, Rainteau D, Benarous D, Maubert MA, Quervain E, Thomas G, Barbu V, Humbert L, Despras G et al: Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 2013, 62(4):531-539.

Kechaou N, Chain F, Gratadoux JJ, Blugeon S, Bertho N, Chevalier C, Le Goffic R, Courau S, Molimard P, Chatel JM et al: Identification of one novel candidate probiotic Lactobacillus plantarum strain active against influenza virus infection in mice by a large-scale screening. Appl Environ Microbiol 2013, 79(5):1491-1499.

Lafont E, Sokol H, Sarre-Annweiler ME, Lecornet-Sokol E, Barete S, Hermine O, Pouchot J, Georgin-Lavialle S: [Causes and differential diagnosis of flush]. Rev Med Interne 2013, 35(5):303-309.

Leblanc JG, Aubry C, Cortes-Perez NG, de Moreno de Leblanc A, Vergnolle N, Langella P, Azevedo V, Chatel JM, Miyoshi A, Bermudez-Humaran LG: Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update. FEMS Microbiol Lett 2013, 344(1):1-9.

Martin R, Miquel S, Ulmer J, Kechaou N, Langella P, Bermudez-Humaran LG: Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease. Microb Cell Fact 2013, 12(1):71.

Mayeur C, Gratadoux JJ, Bridonneau C, Chegdani F, Larroque B, Kapel N, Corcos O, Thomas M, Joly F: Faecal D/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome. PLoS One 2013, 8(1):e54335.

Miquel S, Martin R, Rossi O, Bermudez-Humaran L, Chatel J, Sokol H, Thomas M, Wells J, Langella P: Faecalibacterium prausnitzii and human intestinal health. Curr Opin Microbiol 2013, 16:1-7.

Ribelles P, Benbouziane B, Langella P, Suarez JE, Bermudez-Humaran LG: Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface. Appl Microbiol Biotechnol 2013, 97(3):1231-1239.

Tomas J, Wrzosek L, Bouznad N, Bouet S, Mayeur C, Noordine ML, Honvo-Houeto E, Langella P, Thomas M, Cherbuy C: Primocolonization is associated with colonic epithelial maturation during conventionalization. FASEB J 2013, 27(2):645-655.

Turpin W, Humblot C, Noordine ML, Wrzosek L, Tomas J, Mayeur C, Cherbuy C, Guyot JP, Thomas M: Behavior of lactobacilli isolated from fermented slurry (ben-saalga) in gnotobiotic rats. PLoS One 2013, 8(4):e57711.

Wells JM, Langella P: Ecology and industrial microbiology. Curr Opin Microbiol 2013, 16(3):229-231.

Wrzosek L, Miquel S, Noordine ML, Bouet S, Chevalier-Curt MJ, Robert V, Philippe C, Bridonneau C, Cherbuy C, Robbe-Masselot C et al: Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol 2013, 11(1):61.

Yang L, Nelson RS, Benjdia A, Lin G, Telser J, Stoll S, Schlichting I, Li L: A radical transfer pathway in spore photoproduct lyase. Biochemistry 2013, 52(18):3041-3050.


Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P: Impact of lactobacilli on orally acquired listeriosis. Proc Natl Acad Sci U S A 2012, 109(41):16684-16689.

Benjdia A: DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases. Curr Opin Struct Biol 2012, 22(6):711-720.

Benjdia A, Heil K, Barends TR, Carell T, Schlichting I: Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. Nucleic Acids Res 2012, 40(18):9308-9318.

Ben-Yahia L, Mayeur C, Rul F, Thomas M: Growth advantage of Streptococcus thermophilus over Lactobacillus bulgaricus in vitro and in the gastrointestinal tract of gnotobiotic rats. Benef Microbes 2012, 3(3):211-219.

Cherbuy C, Guesnet P, Morel MT, Kohl C, Thomas M, Duee PH, Prip-Buus C: Oleate metabolism in pig enterocytes is characterized by an increased oxidation rate in the presence of a high esterification rate within two days after birth. J Nutr 2012, 142(2):221-226.

de Azevedo M, Karczewski J, Lefevre F, Azevedo V, Miyoshi A, Wells JM, Langella P, Chatel JM: In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A. BMC Microbiol 2012, 12(1):299.

Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O: Biosynthesis of F(0), Precursor of the F(420) Cofactor, Requires a Unique Two Radical-SAM Domain Enzyme and Tyrosine as Substrate. J Am Chem Soc 2012, 134(44):18173-18176.

Laugerette F, Furet JP, Debard C, Daira P, Loizon E, Geloen A, Soulage CO, Simonet C, Lefils-Lacourtablaise J, Bernoud-Hubac N et al: Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice. Am J Physiol Endocrinol Metab 2012, 302(3):E374-386.

Malleron A, Benjdia A, Berteau O, Le Narvor C: Chondroitin-4-O-sulfatase from Bacteroides thetaiotaomicron: exploration of the substrate specificity. Carbohydr Res 2012, 353:96-99.

Morello E, Nouaille S, Cortes-Perez NG, Blugeon S, Medina LF, Azevedo V, Gratadoux JJ, Bermudez-Humaran LG, Le Loir Y, Langella P: Inactivation of the ybdD Gene in Lactococcus lactis Increases the Amounts of Exported Proteins. Appl Environ Microbiol 2012, 78(19):7148-7151.

Motta JP, Bermudez-Humaran LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P et al: Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med 2012, 4(158):158ra144.

Munoz-Provencio D, Rodriguez-Diaz J, Collado MC, Langella P, Bermudez-Humaran LG, Monedero V: Functional Analysis of the Lactobacillus casei BL23 Sortases. Appl Environ Microbiol 2012, 78(24):8684-8693.

Pierre S, Guillot A, Benjdia A, Sandstrom C, Langella P, Berteau O: Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes. Nat Chem Biol 2012, 8(12):957-959.

Pontes D, Innocentin S, Del Carmen S, Almeida JF, Leblanc JG, de Moreno de Leblanc A, Blugeon S, Cherbuy C, Lefevre F, Azevedo V et al: Production of Fibronectin Binding Protein A at the Surface of Lactococcus lactis Increases Plasmid Transfer In Vitro and In Vivo. PLoS One 2012, 7(9):e44892.

Rochat T, Boudebbouze S, Gratadoux JJ, Blugeon S, Gaudu P, Langella P, Maguin E: Proteomic analysis of spontaneous mutants of Lactococcus lactis: Involvement of GAPDH and arginine deiminase pathway in H2O2 resistance. Proteomics 2012, 12(11):1792-1805.

Santos Rocha C, Lakhdari O, Blottiere HM, Blugeon S, Sokol H, Bermudez-Humaran LG, Azevedo V, Miyoshi A, Dore J, Langella P et al: Anti-inflammatory properties of dairy lactobacilli. Inflamm Bowel Dis 2012, 18(4):657-666.

Tomas J, Langella P, Cherbuy C: The intestinal microbiota in the rat model: major breakthroughs from new technologies. Anim Health Res Rev 2012, 13(1):54-63.

Turpin W, Humblot C, Noordine ML, Thomas M, Guyot JP: Lactobacillaceae and cell adhesion: genomic and functional screening. PLoS One 2012, 7(5):e38034.


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Bermudez-Humaran LG, Kharrat P, Chatel JM, Langella P (2011) Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines. Microb Cell Fact 10 Suppl 1: S4.

Bernard E, Rolain T, Courtin P, Guillot A, Langella P, et al. (2011) Characterization of O-acetylation of N-acetylglucosamine: a novel structural variation of bacterial peptidoglycan.J Biol Chem 286: 23950-23958.

Cauchard S, Bermudez-Humaran LG, Blugeon S, Laugier C, Langella P, et al. (2011) Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection. Vaccine 30: 95-102.

Gloux K, Berteau O, El Oumami H, Beguet F, Leclerc M, et al. (2011) A metagenomic beta-glucuronidase uncovers a core adaptive function of the human intestinal microbiome.Proc Natl Acad Sci U S A 108 Suppl 1: 4539-4546.

LeBlanc JG, del Carmen S, Miyoshi A, Azevedo V, Sesma F, et al. (2011) Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice.J Biotechnol 151: 287-293.

Mondot S, Kang S, Furet JP, Aguirre de Carcer D, McSweeney C, et al. (2011) Highlighting new phylogenetic specificities of Crohn's disease microbiota.Inflamm Bowel Dis 17: 185-192.

Perani A, Gloria B, Wang D, Buffier AS, Berteau O, et al. (2011) Evaluation of an online biomass probe to monitor cell growth and cell death. BMC Proc 5 Suppl 8: P16.

Pontes DS, de Azevedo MS, Chatel JM, Langella P, Azevedo V, et al. (2011) Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems.Protein Expr Purif 79: 165-175.

Rul F, Ben-Yahia L, Chegdani F, Wrzosek L, Thomas S, et al. (2011) Impact of the Metabolic Activity of Streptococcus thermophilus on the Colon Epithelium of Gnotobiotic Rats.J Biol Chem 286: 10288-10296.

Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, et al. (2011) Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS One 6: e16393.

Thomas M, Wrzosek L, Ben-Yahia L, Noordine ML, Gitton C, et al. (2011) Carbohydrate metabolism is essential for the colonization of Streptococcus thermophilus in the digestive tract of gnotobiotic rats. PLoS One 6: e28789.


Adel-Patient K, Pothelune L, Ah-Leung S, Wal JM, Creminon C, et al. (2010) Block copolymers have differing adjuvant effects on the primary immune response elicited by genetic immunization and on further induced allergy. Clin Vaccine Immunol 17: 36-42.

Azais-Braesco V, Bresson JL, Guarner F, Corthier G (2010) Not all lactic acid bacteria are probiotics, ...but some are. Br J Nutr 103: 1079-1081.

Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, et al. (2010) Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes?FEBS J 277: 1906-1920.

Bermudez-Humaran LG, Langella P (2010) Perspectives for the development of human papillomavirus vaccines and immunotherapy. Expert Rev Vaccines 9: 35-44.

Cherbuy C, Honvo-Houeto E, Bruneau A, Bridonneau C, Mayeur C, et al. (2010) Microbiota matures colonic epithelium through a coordinated induction of cell cycle-related proteins in gnotobiotic rat. Am J Physiol Gastrointest Liver Physiol 299: G348-357.

Chiaramonte F, Anglade P, Baraige F, Gratadoux JJ, Langella P, et al. (2010) Analysis of Lactobacillus sakei mutants selected after adaptation to the gastrointestinal tracts of axenic mice.Appl Environ Microbiol 76: 2932-2939.

Cortes-Perez NG, Sapin C, Jaffrelo L, Daou S, Grill JP, et al. (2010) Rotavirus-like particles: a novel nanocarrier for the gut.J Biomed Biotechnol 2010: 317545.

Corthier G, Dore J (2010) [A new era in gut research concerning interactions between microbiota and human health].Gastroenterol Clin Biol 34 Suppl 1: S1-6.

Dore J, Corthier G (2010) [The human intestinal microbiota].Gastroenterol Clin Biol 34 Suppl 1: S7-15.

Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, et al. (2010) Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 59: 3049-3057.

Joly F, Mayeur C, Bruneau A, Noordine ML, Meylheuc T, et al. (2010) Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome. Biochimie 92: 753-761.

LeBlanc JG, del Carmen S, Miyoshi A, Azevedo V, Sesma F, et al. (2010) Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice.J Biotechnol 151: 287-293.

Lhoste EF, Bruneau A, Bensaada M, Cherbuy C, Philippe C, et al. (2010) Apple proanthocyanidins do not reduce the induction of preneoplastic lesions in the colon of rats associated with human microbiota. J Agric Food Chem 58: 4120-4125.

Marinho FA, Pacifico LG, Miyoshi A, Azevedo V, Le Loir Y, et al. (2010) An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model. Clin Exp Allergy 40: 1541-1551.

Mondot S, Kang S, Furet JP, Aguirre de Carcer D, McSweeney C, et al. (2010) Highlighting new phylogenetic specificities of Crohn's disease microbiota. Inflamm Bowel Dis 17: 185-192.

Turpin W, Humblot C, Thomas M, Guyot JP (2010) Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms. Int J Food Microbiol 143: 87-102.

van Loo B, Jonas S, Babtie AC, Benjdia A, Berteau O, et al. (2010) An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.Proc Natl Acad Sci U S A 107: 2740-2745.

Watterlot L, Meyrand M, Gaide N, Kharrat P, Blugeon S, et al. (2010) Variations of N-acetylation level of peptidoglycan do not influence persistence of Lactococcus lactis in the gastrointestinal tract. Int J Food Microbiol 144: 29-34.

Watterlot L, Rochat T, Sokol H, Cherbuy C, Bouloufa I, et al. (2010) Intragastric administration of a superoxide dismutase-producing recombinant Lactobacillus casei BL23 strain attenuates DSS colitis in mice. Int J Food Microbiol 144: 35-41.


Barinov A, Loux V, Hammani A, Nicolas P, Langella P, et al. (2009) Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria. Proteomics 9: 61-73.

Benjdia A, Leprince J, Sandstrom C, Vaudry H, Berteau O (2009) Mechanistic investigations of anaerobic sulfatase-maturating enzyme: direct Cbeta H-atom abstraction catalyzed by a radical AdoMet enzyme. J Am Chem Soc 131: 8348-8349.

Bermudez-Humaran LG (2009) Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins. Hum Vaccin 5: 264-267.

Chiaramonte F, Blugeon S, Chaillou S, Langella P, Zagorec M (2009) Behavior of the meat-borne bacterium Lactobacillus sakei during its transit through the gastrointestinal tracts of axenic and conventional mice. Appl Environ Microbiol 75: 4498-4505.

Cortes-Perez NG, Ah-Leung S, Bermudez-Humaran LG, Corthier G, Langella P, et al. (2009) Allergy therapy by intranasal administration with recombinant Lactococcus lactis Producing bovine beta-lactoglobulin. Int Arch Allergy Immunol 150: 25-31.

Cortes-Perez NG, Kharrat P, Langella P, Bermudez-Humaran LG (2009) Heterologous production of human papillomavirus type-16 L1 protein by a lactic acid bacterium. BMC Res Notes 2: 167.

Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, et al. (2009) Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. Gut 58: 771-776.

Furet JP, Firmesse O, Gourmelon M, Bridonneau C, Tap J, et al. (2009) Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR.FEMS Microbiol Ecol 68: 351-362.

Guimaraes V, Innocentin S, Chatel JM, Lefevre F, Langella P, et al. (2009) A new plasmid vector for DNA delivery using lactococci. Genet Vaccines Ther 7: 4.

Hazebrouck S, Przybylski-Nicaise L, Ah-Leung S, Adel-Patient K, Corthier G, et al. (2009) Influence of the route of administration on immunomodulatory properties of bovine beta-lactoglobulin-producing Lactobacillus casei. Vaccine 27: 5800-5805.

Hazebrouck S, Przybylski-Nicaise L, Ah-Leung S, Adel-Patient K, Corthier G, et al. (2009) Allergic sensitization to bovine beta-lactoglobulin: comparison between germ-free and conventional BALB/c mice. Int Arch Allergy Immunol 148: 65-72.

Innocentin S, Guimaraes V, Miyoshi A, Azevedo V, Langella P, et al. (2009) Lactococcus lactis expressing either Staphylococcus aureus fibronectin-binding protein A or Listeria monocytogenes internalin A can efficiently internalize and deliver DNA in human epithelial cells. Appl Environ Microbiol 75: 4870-4878.

Joly F, Mayeur C, Messing B, Lavergne-Slove A, Cazals-Hatem D, et al. (2009) Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. Am J Physiol Gastrointest Liver Physiol 297: G116-123.

Mariat D, Firmesse O, Levenez F, Guimaraes V, Sokol H, et al. (2009) The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 9: 123.

Mieszkin S, Furet JP, Corthier G, Gourmelon M (2009) Estimation of pig fecal contamination in a river catchment by real-time PCR using two pig-specific Bacteroidales 16S rRNA genetic markers. Appl Environ Microbiol 75: 3045-3054.

Oliveira MN, Almeida KE, Damin MR, Rochat T, Gratadoux JJ, et al. (2009) Behavior and viability of spontaneous oxidative stress-resistant Lactococcus lactis mutants in experimental fermented milk processing. Genet Mol Res 8: 840-847.

 Pang QF, Ji Y, Bermudez-Humaran LG, Zhou QM, Hu G, et al. (2009) Protective effects of a heme oxygenase-1-secreting Lactococcus lactis on mucosal injury induced by hemorrhagic shock in rats. J Surg Res 153: 39-45.

Sokol H, Seksik P, Furet JP, Firmesse O, Nion-Larmurier I, et al. (2009) Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 15: 1183-1189.

Tap J, Mondot S, Levenez F, Pelletier E, Caron C, et al. (2009) Towards the human intestinal microbiota phylogenetic core. Environ Microbiol 11: 2574-2584.


Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O. Anaerobic sulfatase-maturating enzymes - first dual substrate radical S-adenosylmethionine enzymes. J Biol Chem 2008; 283:17815-26.

Bermudez-Humaran LG, Cortes-Perez NG, Ah-Leung S, Lefevre F, Yang G, Pang Q, Wu C, Zeng Y, Adel-Patient K, Langella P. Current prophylactic and therapeutic uses of a recombinant Lactococcus lactis strain secreting biologically active interleukin-12. J Mol Microbiol Biotechnol 2008; 14:80-9.

Bermudez-Humaran LG, Cortes-Perez NG, L'Haridon R, Langella P. Production of biological active murine IFN-gamma by recombinant Lactococcus lactis. FEMS Microbiol Lett 2008; 280:144-9.

Chandor-Proust A, Berteau O, Douki T, Gasparutto D, Ollagnier-de-Choudens S, Fontecave M, Atta M. DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitution. J Biol Chem 2008; 283:36361-8.

Chatel JM, Pothelune L, Ah-Leung S, Corthier G, Wal JM, Langella P. In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells. Gene Ther 2008; 15:1184-90.

Cortes-Perez NG, da Costa Medina LF, Lefevre F, Langella P, Bermudez-Humaran LG. Production of biologically active CXC chemokines by Lactococcus lactis: evaluation of its potential as a novel mucosal vaccine adjuvant. Vaccine 2008; 26:5778-83.

de Moreno de LeBlanc A, LeBlanc JG, Perdigon G, Miyoshi A, Langella P, Azevedo V, Sesma F. Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice. J Med Microbiol 2008; 57:100-5.

Firmesse O, Alvaro E, Mogenet A, Bresson JL, Lemee R, Le Ruyet P, Bonhomme C, Lambert D, Andrieux C, Dore J, Corthier G, Furet JP, Rigottier-Gois L. Fate and effects of Camembert cheese micro-organisms in the human colonic microbiota of healthy volunteers after regular Camembert consumption.Int J Food Microbiol 2008; 125:176-81.

Firmesse O, Mogenet A, Bresson JL, Corthier G, Furet JP. Lactobacillus rhamnosus R11 consumed in a food supplement survived human digestive transit without modifying microbiota equilibrium as assessed by real-time polymerase chain reaction. J Mol Microbiol Biotechnol 2008; 14:90-9.

Mater DD, Langella P, Corthier G, Flores MJ. A probiotic Lactobacillus strain can acquire vancomycin resistance during digestive transit in mice. J Mol Microbiol Biotechnol 2008; 14:123-7.

Medina M, Villena J, Salva S, Vintini E, Langella P, Alvarez S. Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae. Microbiol Immunol 2008; 52:399-409.

Morello E, Bermudez-Humaran LG, Llull D, Sole V, Miraglio N, Langella P, Poquet I. Lactococcus lactis, an efficient cell factory for recombinant protein production and secretion. J Mol Microbiol Biotechnol 2008; 14:48-58.

Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottiere HM, Dore J, Marteau P, Seksik P, Langella P. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 2008; 105:16731-6.