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Philippe Noirot

PhD, Vice-Director of MICALIS Institute (UMR1319/INRA-AgroParisTech), Manager of the "Systemic and Synthetic Biology" Pole, INRA Research Director - Head of FICP Team,
  • Philippe NOIROT
  • Position : Vice-director of MICALIS Institute ; Head of the BioSys Pole ; INRA Research Director ; Head of FICP Team
  • In the lab since : 1998
  • Email : philippe.noirot[at]jouy.inra.fr
  • Tel : +33 (0) 1 34 65 25 14

Project description

Dr Noirot has been the coordinator of BaSysBio, a FP6 large integrated project (2006-2011) focused on developing a systems biology approach to understand the transcriptional regulatory structure in B. subtilis (http://www.basysbio.eu). His laboratory is actively identifying binary protein interactions (yeast two-hybrid), multi-protein complexes (TAP), and genome-wide DNA binding sites (ChIP-chip), in close collaboration with the "Mathématique, Informatique et Génome" (MIG) laboratory at INRA. Dr Noirot’s laboratory also carries out the experimental effort to minimize the B. subtilis genome, in close collaboration with Dr R.L. Stevens’ laboratory (Computation Institute, University of Chicago). He is the coordinator of BaSynthec, a FP7 collaborative project focused on developing synthetic approaches for B. subtilis biotechnology (http://basynthec.eu).

Publications

- DELUMEAU, O., F. LECOINTE, J. MUNTEL, A. GUILLOT, E. GUEDON, V. MONNET, M. HECKER, D. BECHER, P. POLARD & P. NOIROT, (2011) The dynamic protein partnership of RNA polymerase in Bacillus subtilis. Proteomics 11: 2992-3001.
- MARCHADIER, E., R. CARBALLIDO-LÓPEZ, S. BRINSTER, C. FABRET, P. MERVELET, P. BESSIÈRES, M. F. NOIROT-GROS, V. FROMION & P. NOIROT, (2011) An expanded protein-protein interaction network in Bacillus subtilis reveals a group of hubs: Exploration by an integrative approach. Proteomics 11: 2981-2991.
- PONCET, S., M. SORET, P. MERVELET, J. DEUTSCHER & P. NOIROT, (2009) Transcriptional activator YesS is stimulated by histidine-phosphorylated HPr of the Bacillus subtilis phosphotransferase system. J. Biol. Chem. 284: 28188-28197.

Curriculum Vitae

Dr. Philippe Noirot is head of Systems biology and deputy director of the joint INRA/AgroParisTech Micalis Institute. He received a Ph.D in molecular genetics (university Paris-sud, Orsay,France) with Dr. S.D. Ehrlich. He then worked as a post-doctoral fellow with Dr. R. P. Novick (PHRI, New York), and later with Dr R.D. Kolodner (DFCI, Harvard Medical School, Boston). In 1998, he became head of a research group focused on studying chromosome dynamics using interactomics associated with functional genomics and chromosome engineering techniques.

Writing: Philippe Noirot
Creation date: 14 April 2011
Update: 07 September 2011