Stéphane Aymerich, Director of Research at INRA, is the co-leader of the team and he is also leading the Micalis Institute. His main research interest is genetic regulation in prokaryotes.
S. Aymerich obtained his Ph.D in 1987 in the Department of Microbiology of the Institut Jacques Monod (Paris) studying the regulation of the expression of the levansucrase gene of Bacillus subtilis under the supervision of Dr. Michel Steinmetz. He carried out post-doctoral studies at the Oswaldo Cruz Foundation (Rio de Janeiro, Brazil) in Dr. Samuel Goldenberg group, working on the characterization of the karyotype of trypanosomatids. He then took a permanent position of junior scientist at INRA in the Genetics of Microorganisms Unit headed by the Pr. Henri Heslot, studying in B. subtilis a new regulatory mechanism by transcriptional anti-termination, at the genetic, molecular and then structural level. He created his own group and took in 1997 a position of Director of Research in the same Unit headed at that time by Pr. Claude Gaillardin. His group has been strongly involved in different EU programs for B. subtilis functional genomics, focusing on new catalytic and regulatory functions of the central carbon metabolism. More he has developed projects of systems biology in collaboration with Uwe Sauer (ETHZ, Zürich) and Vincent Fromion (INRA, Jouy-en-Josas), notably in the framework of the EU BaSysBio and BaSynthec programs coordinated by Philippe Noirot (INRA, Jouy-en-Josas). S. Aymerich is coordinating the ALIAS (The Food-Health connection: Providing health benefits and lowering risks of disease through food and diet) project funded by the Paris-Saclay IDEX.
S. Aymerich has participated to numerous scientific advisory boards (INRA and INRA Divisions) and review panels (CNRS, CEA, ANR and INRA). He has published a total of 59 articles in peer-reviewed journals.
Five recent publications (the others can be found in the team's publications section):
- Houry A, Gohar M, Deschamps J, Tischenko E, Aymerich S, Gruss A, Briandet R. Bacterial swimmers that infiltrate and take over the biofilm matrix. Proc NatlAcad Sci U S A. 2012;109(32):13088-93.
- Rühl M, Le Coq D, Aymerich S, Sauer U. 13C-flux analysis reveals NADPH-balancing transhydrogenation cycles in stationary phase of nitrogen-starving Bacillus subtilis. J Biol Chem. 2012;287(33):27959-70.
- Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E, Hessling B, Kleijn RJ, Le Chat L, Lecointe F, Mäder U, Nicolas P, Piersma S, Rügheimer F, Becher D, Bessieres P, Bidnenko E, Denham EL, Dervyn E, Devine KM, Doherty G, Drulhe S, Felicori L, Fogg MJ, Goelzer A, Hansen A, Harwood CR, Hecker M, Hubner S, Hultschig C, Jarmer H, Klipp E, Leduc A, Lewis P, Molina F, Noirot P, Peres S, Pigeonneau N, Pohl S, Rasmussen S, Rinn B, Schaffer M, Schnidder J, Schwikowski B, Van Dijl JM, Veiga P, Walsh S, Wilkinson AJ, Stelling J, Aymerich S, Sauer U. Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science. 2012;335(6072):1099-103.
- Ferguson ML, Le Coq D, Jules M, Aymerich S, Radulescu O, Declerck N, Royer CA. Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states. Proc Natl Acad Sci U S A. 2012;109(1):155-60.
- Meyer FM, Jules M, Mehne FM, Le Coq D, Landmann JJ, Görke B, Aymerich S, Stülke J. Malate-mediated carbon catabolite repression in Bacillus subtilis involves the HPrK/CcpA pathway. J Bacteriol. 2011;193(24):6939-49.