En naviguant sur notre site vous acceptez l'installation et l'utilisation des cookies sur votre ordinateur. En savoir +






Van Hul M, Geurts L, Plovier H, Druart C, Everard A, Ståhlman M, Rhimi M, Chira K, Teissedre PL, Delzenne NM, Maguin E, Guilbot A, Brochot A, Gerard P, Bäckhed F, Cani PD. Reduced obesity, diabetes and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier. Am J Physiol Endocrinol Metab. 2017 Sep 5:ajpendo.00107.2017. doi: 10.1152/ajpendo.00107.2017.

Cassard AM, Gérard P, Perlemuter G. Microbiota, Liver Diseases, and Alcohol. Microbiol Spectr. 2017 Aug;5(4). doi: 10.1128/microbiolspec.BAD-0007-2016.

Mach N, Foury A, Kittelmann S, Reigner F, Moroldo M, Ballester M, Esquerré D, Rivière J, Sallé G, Gérard P, Moisan M-P and Lansade L (2017) The Effects of Weaning Methods on Gut Microbiota Composition and Horse Physiology. Front. Physiol. 8:535. doi: 10.3389/fphys.2017.00535

Gérard P Microbiote intestinal et obésité. Diabète et Obésité infirmiers, 2017, 12 :22-23 (review)

Gérard P Les microbes font-ils grossir ? Dossier Pour la Science, Avril-Juin 2017, N°95 : 58-65 (review)

Cassard AM, Gérard P, Perlemuter G. Microbiote et foie : maladies hépatiques métaboliques et nutritionnelle. In « Le Microbiote intestinal : un organe à part entière ». Editions John Libbey. Coordination Marteau P et Doré J, 2017, pp 201-211 (book chapter).

Rabot S, Naudon L, Daugé V. Microbiote intestinal et maladies psychiatriques et neurodégénératives. In « Le Microbiote intestinal : un organe à part entière ». Editions John Libbey. Coordination Marteau P et Doré J, 2017, pp 247-256 (book chapter).

Wegner K, Just S, Gau L, Mueller H, Gérard P, Lepage P, Clavel T, Rohn S. Rapid analysis of bile acids in different biological matrices using LC-ESI-MS/MS for the investigation of bile acid transformation by mammalian gut bacteria. Anal Bioanal Chem, 2017 Feb;409(5):1231-1245.

Heberden C and Maximin E (2017) Epigenetic effects of n-3 poly unsaturated fatty acids. Springer International Publishing AG 2017 V.R. Preedy, V.B. Patel (eds.), Handbook of Nutrition, Diet, and Epigenetics,DOI 10.1007/978-3-319-31143-2_45-1

Heberden C (2017) Sex steroids and neurogenesis Biochem Pharmacol . 141, 56-62

Oberli M, DOUARD V, Beaumont M, Jaoui D, Devime F, Laurent S, Chaumontet C, Mat D, Le Feunteun S, , Michon C , Davila AM, Fromentin G , Tomé D, Souchon I, Leclerc M, Gaudichon C, Blachier F. (2017) Lipo-protein emulsion structure in the diet affects protein digestion kinetics, intetsinal mucosa parameters and microbiota composition. Mol Nutr Food Res. 2017 Septembre 29. DOI: 10.1002/mnfr.201700570

Beaumont M, Jaoui D, DOUARD V, Mat D, Koeth F, Goustard B, Mayeur C, Mondot S, Hovaghimian A, Le Feunteun S, Chaumontet C, Davila AM, Tomé D, Souchon I, Michon C, Fromentin G, Blachier F, Leclerc M. (2017) Structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats. Mol Nutr Food Res. 2017 May 17. doi: 10.1002/mnfr.201700078


François A, Grebert D, Rhimi M, Mariadassou M, Naudon L, Rabot S, Meunier N. 2016. Olfactory epithelium changes in germfree mice. Scientific Reports 6: 24687


Rabot S, Membrez M, Blancher F, Berger B, Moine D, Krause L, Bibiloni R, Bruneau A, Gérard P, Siddharth J, Lauber CL, Chou CJ. High fat diet drives obesity regardless the composition of gut microbiota in mice. Scientific Reports 6: 32484


Llopis M, Cassard-Doulcier AM,  Wrosek L, Boschat L, Ferrere G, Bruneau A, Puchois V, Martin JC,  Lepage P, Le Roy T, Lefèvre L, Langelier B, Cailleux F, González-Castro AM, Rabot S, Gaudin F,  Agostini H, Prévot S,  Berrebi D, Ciocan D, Jousse C, Naveau S, Gérard P, Perlemuter G. Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease. Gut, 2016, 65(5):830-9.


Reygner J, Joly Condette C, Bruneau A, Delanaud S, Rhazi L, Depeint F, Abdennebi-Najar L, Bach V, Mayeur C, Khorsi-Cauet H. Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME® Model. Int J Environ Res Public Health. 2016 Nov 4;13(11). pii: E1088.


Neasta J, Valmalle C, Coyne AC, Carnazzi E, Subra G, Galleyrand JC, Gagne D, M'Kadmi C, Bernad N, Bergé G, Cantel S, Marin P, Marie J, Banères JL, Kemel ML, Daugé V, Puget K, Martinez J. The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release. Br J Pharmacol. 2016 Apr;173(8):1314-28. doi: 10.1111/bph.13424


Rabot S, Jaglin M, Daugé V, Naudon L. Impact of the gut microbiota on the neuroendocrine and behavioural responses to stress in rodents. OCL 23(1): D116 (Review)


Gérard P. Targeting the Gut Microbiota in Obesity? Ann Obes Disord. 2016; 1(3): 1011. (Review)


Gérard P. Gut microbiota and obesity. Cellular and Molecular Life Sciences , 2016, 73:147-62. (Review)


Gérard P, Ritz P. Microbiote intestinal, obésité et troubles métaboliques associés. La Revue des Microbiotes, 2016, 4 :4-11. (Review)


Gérard P Microbiote et obésité : quels liens ? Diabète et Obésité, 2016, 11 :181-184. (Review)


Rincel M, Lépinay A, Gabory A, Théodorou V, Koehl M, Daugé V, Maccari S, Darnaudéry M. Environnement précoce et vulnérabilité neuropsychiatrique Med Sci (Paris). 2016 Jan;32(1):93-9.  (Review)

Maximin E., Goustard-Langelier B., Aïoun J., Al-Gubory K., Bordat C., Lavialle M., Heberden C. (2016) Effects of n-3 polyunsaturated fatty acid and role of FABP7 on early rat brain development. Dev Neurobiol, 39, 287-297

Heberden C (2016) Modulating adult neurogenesis through dietary interventions. Nutr Res Rev 29  163-171

Wang Y, Dellatore P, DOUARD V, Qin L, Watford M, Ferraris RP, Lin T, Shapses SA. (2016) High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice. Nutr Res. 2016 Jul;36(7):742-50.


Tap J., Furet J.P., Bensaada M., Philippe C., Roth H., Rabot S., Lakhdari O., Lombard V., Henrissat B., Corthier G., Fontaine E., Doré J., Leclerc M. Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults. Environ Microbiol, 2015, 17(12): 4954-64.


Tesone-Coelho C, Morel LJ, Bhatt J, Estevez L, Naudon L, Giros B, Zwiller J, Daugé V. Vulnerability to opiate intake in maternally deprived rats: implication of MeCP2 and of histone acetylation. Addict Biol. 2015 Jan;20(1):120-31.


Potiron A, Gérard P, Le Roy T, Lesnik P, Maguin E, Rhimi M. Recent Patents on Hypocholesterolemic Therapeutic Strategies: An Update, Recent Adv DNA Gene Seq, 2015, 9:36-44. (Review)


Gérard P. Microbiote, alcool et foie, Correspondances en Métabolismes Hormones Diabètes et Nutrition, 2015, 19 :142-44 (Review)


Gérard P Microbiote intestinal, cholestérol et maladies cardio-vasculaires, Pratiques en Nutrition, 2015, 41 :43-45 (Review)


Gérard P.  Obésité. La flore intestinale mise en cause. Pour la science, 2015, 447 :34-40 (Review)


Daugé V, Jaglin M, Naudon L, Rabot S. Les maladies mentales viennent-elles du ventre ? Pour la science, 2015, 447 :42-48 (Review)


Gérard P. Microbiote, alcool et foie, Correspondances en Métabolismes Hormones Diabètes et Nutrition, 2015, 19 :142-44. (Review)


Gérard P Microbiote intestinal et lipides. Lipid’Nutri N°28, 2015, 5 pages.  (Review)


Lepage P, Gérard P. Microbiote intestinal et typage. In « La métagénomique : développements actuels et futures perspectives ». Editions Quae. Coordination Champommier-Vergès M et Zagorec M, 2015. pp51-56. (Book chapter)

Denis I., Potier B., Heberden C, Vancassel S. (2015) Omega-3 polyunsaturated fatty acids and brain aging; Curr Opin. Clin Nutr Metab Care 2015, 18:139–146

Patel C, Sugimoto K, DOUARD V, Shah A, Inui H, Yamanouchi T, Ferraris RP. (2015) Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice. Am J Physiol Gastrointest Liver Physiol. Nov 1;309(9):G779-90

Patel C, DOUARD V, Yu S, Tharabenjasin P, Gao N, Ferraris RP (2015) Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK. Am J Physiol Regul Integr Comp Physiol. Sep;309(5):R499-509

C Patel, V DOUARD, S Yu, N Gao, RP Ferraris (2015) Transport, metabolism and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J. Sep;29(9):4046-58.


Crumeyrolle-Arias M, Jaglin M, Bruneau A, Vancassel S, Cardona A, Daugé V, Naudon L, Rabot S. Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats. Psychoneuroendocrinology, 42, 207-217


Ziar H, Gérard P, Riazi A. Bile Salt Hydrolase, Bile Survival and Cholesterol-lowering activities of lactic acid bacteria  could be improved by prebiotics. J Sci Food Agric, 2014, 94:1184-1190.


Gérard P. Metabolism of Cholesterol and Bile Acids by the Gut Microbiota. Pathogens. 2014; 3(1):14-24. Pathogens Best Paper Award 2015 (Review)


Duca F, Gérard P, Covasa M, Lepage P. The metabolic interplay between gut bacteria and their host. Front Horm Res. 2014;42:73-82. (Review)


Desmarcherlier C, Haller D, Gérard P, Rohn S, Lepage P, Daniel H, Clavel C. Intestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance. Gut Microbes, 2014, 5(4):1-8. (Review)


Gérard P.  Microbiote intestinal, obésité et pathologies associées. Biologiste infos, 2014, 71, 22-24. (Review)


Gérard P.  Les relations entre microbiote intestinal et lipides. Cahiers de Nutrition et de Diététique, 2014, 49 :213-217. (Review)


Gérard P.  Microbiote intestinal, obésité et pathologies associées. Nutritions infos, 2014, 39, 23-27. (Review)


Gérard P.  Microbiote intestinal et lipides : impact sur la santé humaine, Nutritions & Endocrinologie, 2014 ; 12 :127-9. (Review)

V DOUARD, C Patel, J Lee, P Tharabenjasin, E Williams, JC. Fritton, Y Sabbagh, RP Ferraris. (2014). Chronic high fructose intake reduces serum 1,25(OH)2D3 levels in calcium-sufficient rodent PlosOne April 9: 9(4)e93611.


S Yu, Y Nie, B Knowles, R Sakamori, E Stypulkowski, S Das, V DOUARD, CS Yang, RP Ferraris, EM Bonder, JR Goldenring, YP Ip, N Gao. (2014) TLR sorting by Rab11 endosome in enterocyte maintains intestinal Epithelial-microbiotal homeostasis. EMBO J, Sep 1;33(17):1882-95.


Le Roy T, Llopis M, Lepage P, Bruneau A, Rabot S, Bevilacqua C, Martin P, Philippe C, Walker F, Bado A, Perlemuter G, Cassard-Doulcier AM, Gérard P. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut, 2013; 62:1787-1794.


Lejeune S, Dourmap N, Martres MP, Giros B, Daugé V, Naudon L. The dopamine D1 receptor agonist SKF 38393 improves temporal order memory performance in maternally deprived rats. Neurobiol Learn Mem. 2013 Nov;106:268-73. doi: 10.1016/j.nlm.2013.10.005.


Naudon L, Piscitelli F, Giros B, Di Marzo V, Daugé V. Possible involvement of endocannabinoids in the increase of morphine consumption in maternally deprived rat. Neuropharmacology. 2013 Feb;65:193-9. doi: 10.1016/j.neuropharm.2012.10.008.


Ouethrani M, Van de Wiele T, Verbeke E, Bruneau A, Carvalho M, Rabot S, Camel V. Metabolic fate of ochratoxin A as a coffee contaminant in a dynamic simulator of the human colon. Food Chem. 2013 Dec 15;141(4):3291-300. doi: 10.1016/j.foodchem.2013.05.157.


Wrzosek L, Miquel S, Noordine ML, Bouet S, Joncquel Chevalier-Curt M, Robert V, Philippe C, Bridonneau C, Cherbuy C, Robbe-Masselot C, Langella P, Thomas M. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol. 2013 May 21;11:61. doi: 10.1186/1741-7007-11-61


Respondek F, Gérard P, Bossis M, Boschat L, Bruneau A, Rabot S, Wagner A, Martin JC. Short-chain fructo-oligosaccharides modulate intestinal microbiota and metabolic parameters of human microbiota-associated diet induced obesity mice. PlosOne. 2013, 8:e71026.


Dhurandhar NV, Geurts L, Atkinson RL, Casteilla L, Clement K, Gérard P, Vijay-Kumar M, Nam JH, Nieuwdorp M, Trovato G, Sørensen TIA, Vidal-Puig A, Cani PD.  Harnessing the Beneficial Properties of Adipogenic Microbes for Improving Human Health.  Obes Rev. 2013, 14:721-35. (Review)


Gérard P Microbiote et santé : exemple de la stéatose hépatique. NAFAS, 2013 ;11(5) :25-28. (Review)

Le Roy T, Doré J, Gérard P Microbiote et athérosclérose. Cardiologie cardinale. 2013;7(57):207-12. (Review)

Gérard P.  Impact du vieillissement sur le microbiote intestinal, Pratiques en Nutrition, 2013 ; 35:23-5. (Review)

Gérard P.  Microbiote intestinal, obésité et pathologies associées. Actualités en Diététique et Nutrition, 2013, 105-12. (Review)

Le Roy T, Doré J, Gérard P Microbiote et athérosclérose. Identification d’un nouveau facteur environnemental. Diabète et Obésité. 2013;8:84-90. (Review)

Goustard-Langelier B, Koch M, Lavialle M, Heberden C (2013) Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. Journal of Nutritional Biochemistry. 24: 380-387.

Heberden C, Meffray E, Langelier B, Maximin E, Lavialle M (2013) Dexamethasone impairs the differentiation of polyunsaturated fatty acid-supplemented neural stem cells. J. Steroid Biochem. Mol. Biol. 128: 395-402.

Denis I., Potier B., Vancassel S., Heberden C., Lavialle M. (2013) Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms. Ageing Res. Reviews. 12: 579-594.

Sélection de publications

Le Roy T, Llopis M, Lepage P, Bruneau A, Rabot S, Bevilacqua C, Martin P, Philippe C, Walker F, Bado A, Perlemuter G, Cassard-Doulcier AM, Gérard P. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut. 2012 Nov 29, in press.

Van den Abbeele P, Gérard P, Rabot S, Bruneau A, El Aidy S, Derrien M, Kleerebezem M, Zoetendal E, Smidt H, Verstraete W, Van de Wiele T, Possemiers S. Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiome and mucin degradation in humanized rats, Environmental Microbiology, 2011, 13:2667-80.

Rabot S, Membrez M, Bruneau A, Gérard P, Harach T, Moser M, Raymond F, Mansourian R, Macé K, Chou CJ. Germfree C57BL/6J mice are resistant to high fat diet-induced insulin resistance and have altered cholesterol metabolism, Faseb Journal, 2010, 24:4948-4959.

Van den Abbeele P, Grootaert C, Marzorati M, Possemiers S, Verstraete W, Gérard P, Rabot S, Bruneau A, El Aidy S, Derrien M, Zoetendal E, Kleerebezem M, Smidt H, Van de Wiele T. Microbial community development in a dynamic gut model is reproducible, colon region specific and selective for Bacteroidetes and Clostridium Cluster IX. Applied and Environmental Microbiology, 2010, 76: 5237–5246.

Rabot S, Rafter J, Rijkers GT, Watzl B, Antoine J-M. Guidance for substantiating the evidence for the beneficial effects of probiotics: impact of probiotics on digestive system metabolism. J Nutr. 2010;140(3) 677S-89S.

Crumeyrolle-Arias M, Tournaire MC, Rabot S, Malpaux B, Thiéry JC. 5-hydroxyoxindole, an indole metabolite, is present at high concentrations in brain. Journal of Neuroscience Research, 2008, 86, 202-7.

Possemiers S, Rabot S, Espín JC, Bruneau A, Philippe C, Gonzáles-Sarrías A, Heyerick A, Tomás-Barberán FA, De Keukeleire D, Verstraete W. Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine. J Nutr. 2008;138(7):1310-6.

Gerard P, Lepercq P, Leclerc M, Gavini F, Raibaud P, Juste C. Bacteroides sp. Strain d8, the first cholesterol-reducing bacterium isolated from human feces. Applied and Environmental Microbiology, 2007;73:5742-5749

Humblot C, Murkovic M, Rigottier-Gois L, Bensaada M, Bouclet A, Andrieux C, Anba J, Rabot S. β-Glucuronidase in human intestinal microbiota is necessary for the colonic genotoxicity of the food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Carcinogenesis, 2007, 28, 2419-25.