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Publications de BIMLip




Back A, Rossignol T, Krier F, Nicaud J-M & Dhulster P (2016) High-throughput fermentation screening for the yeast Yarrowia lipolytica with real-time monitoring of biomass and lipid production. Microbial Cell Factories15: 147.

Dulermo R, Gamboa-Meléndez H, Ledesma‐Amaro R, Thevenieau F & Nicaud J-M (2016) Yarrowia lipolytica AAL genes are involved in peroxisomal fatty acid activation. Biochim Biophys Acta1861: 555-565.

Gajdoš P, Ledesma-Amaro R, Nicaud J-M, Čertík M & Rossignol T (2016) Overexpression of diacylglycerol acyltransferase in arrowia lipolytica affects lipid body size, number and distribution. FEMS Yeast Res16.

Ledesma-Amaro R & Nicaud J-M (2016) Metabolic Engineering for Expanding the Substrate Range of Yarrowia lipolytica. Trends Biotechnol34: 798-809.

Ledesma-Amaro R & Nicaud J-M (2016) Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids. Progress in Lipid Research61: 40-50.

Ledesma-Amaro R, Dulermo R, Niehus X & Nicaud J-M (2016) Combining metabolic engineering and process optimization to improve production and secretion of fatty acids. Metab Eng38: 38-46.

Ledesma-Amaro R, Lazar Z, Rakicka M, Guo Z, Fouchard F, Coq A-MC-L & Nicaud J-M (2016) Metabolic engineering of Yarrowia lipolytica to produce chemicals and fuels from xylose. Metab Eng38: 115-124.


Dulermo R, Gamboa-Melendez H, Ledesma-Amaro R, Thevenieau F & Nicaud JM (2015) Unraveling fatty acid transport and activation mechanisms in Yarrowia lipolytica. Biochim Biophys Acta 1851: 1202-1217.

Dulermo R, Dulermo T, Gamboa-Melendez H, Thevenieau F & Nicaud JM (2015) Role of Pex11p in Lipid Homeostasis in Yarrowia lipolytica. Eukaryot Cell 14: 511-525.

Dulermo R, Gamboa-Melendez H, Michely S, Thevenieau F, Neuveglise C & Nicaud JM (2015) The evolution of Jen3 proteins and their role in dicarboxylic acid transport in Yarrowia. Microbiologyopen 4: 100-120.

Dulermo T, Lazar Z, Dulermo R, Rakicka M, Haddouche R & Nicaud JM (2015) Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis. Biochim Biophys Acta 1851: 1107-1117.

Gajdos P, Nicaud JM, Rossignol T & Certik M (2015) Single cell oil production on molasses by Yarrowia lipolytica strains overexpressing DGA2 in multicopy. Appl Microbiol Biotechnol [Epub ahead of print].

Leplat, C., Nicaud, J.-M., Rossignol, T., (2015). High-throughput transformation method for Yarrowia lipolytica mutant library screening.FEMS Yeast Res [Epub ahead of print]


Beopoulos A, Verbeke J, Bordes F, Guicherd M, Bressy M, Marty A & Nicaud JM (2014) Metabolic engineering for ricinoleic acid production in the oleaginous yeast Yarrowia lipolytica. Appl Microbiol Biotechnol 98: 251-262.

Dulermo R, Gamboa-Melendez H, Dulermo T, Thevenieau F & Nicaud JM (2014) The fatty acid transport protein Fat1p is involved in the export of fatty acids from lipid bodies in Yarrowia lipolytica. FEMS Yeast Res 14: 883-896.

Duquesne S, Bozonnet S, Bordes F, Dumon C, Nicaud JM & Marty A (2014) Construction of a highly active xylanase displaying oleaginous yeast: comparison of anchoring systems. PLoS One 9: e95128.

Janbon, G., Ormerod, K.L., Paulet, D., Byrnes, E.J., 3rd, Yadav, V., Chatterjee, G., Mullapudi, N., Hon, C.C., Billmyre, R.B., Brunel, F., Bahn, Y.S., Chen, W., Chen, Y., Chow, E.W., Coppee, J.Y., Floyd-Averette, A., Gaillardin, C., Gerik, K.J., Goldberg, J., Gonzalez-Hilarion, S., Gujja, S., Hamlin, J.L., Hsueh, Y.P., Ianiri, G., Jones, S., Kodira, C.D., Kozubowski, L., Lam, W., Marra, M., Mesner, L.D., Mieczkowski, P.A., Moyrand, F., Nielsen, K., Proux, C., Rossignol, T., Schein, J.E., Sun, S., Wollschlaeger, C., Wood, I.A., Zeng, Q., Neuveglise, C., Newlon, C.S., Perfect, J.R., Lodge, J.K., Idnurm, A., Stajich, J.E., Kronstad, J.W., Sanyal, K., Heitman, J., Fraser, J.A., Cuomo, C.A., Dietrich, F.S., (2014). Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. 10, e1004261.

Lazar Z, Dulermo T, Neuveglise C, Crutz-Le Coq AM & Nicaud JM (2014) Hexokinase-A limiting factor in lipid production from fructose in Yarrowia lipolytica. Metab Eng 26C: 89-99.

Maguire SL, Wang C, Holland LM, Brunel F, Neuveglise C, Nicaud JM, Zavrel M, White TC, Wolfe KH & Butler G (2014) Zinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolution. PLoS Genet 10: e1004076.

Morin N, Calcas X, Devillers H, Durrens P, Sherman DJ, Nicaud JM & Neuveglise C (2014) Draft Genome Sequence of Rhodosporidium toruloides CECT1137, an Oleaginous Yeast of Biotechnological Interest. Genome Announc 2.

Morin, N., Crutz-Le Coq, A.-M., Rossignol, T., Nicaud, J.-M., (2014). Protocols for Monitoring Growth and Lipid Accumulation in Oleaginous Yeasts. In: T. J. McGenity (Ed.), Hydrocarbon and Lipid Microbiology Protocols, Humana Press, pp. 1-17.


Dulermo T, Treton B, Beopoulos A, Kabran Gnankon AP, Haddouche R & Nicaud JM (2013) Characterization of the two intracellular lipases of Y. lipolytica encoded by TGL3 and TGL4 genes: new insights into the role of intracellular lipases and lipid body organisation. Biochim Biophys Acta 1831: 1486-1495.

Lazar Z, Rossignol T, Verbeke J, Crutz-Le Coq AM, Nicaud JM & Robak M (2013) Optimized invertase expression and secretion cassette for improving Yarrowia lipolytica growth on sucrose for industrial applications. J Ind Microbiol Biotechnol 40: 1273-1283.

Michely, S., Gaillardin, C., Nicaud, J. M. and Neuveglise, C. (2013). Comparative physiology of oleaginous species from the yarrowia clade. PLoS One 8, e63356

Verbeke, J., Beopoulos, A. and Nicaud, J. M. (2013). Efficient homologous recombination with short length flanking fragments in Ku70 deficient Yarrowia lipolytica strains. Biotechnol Lett 35, 571-6.

Papanikolaou S, Beopoulos A, Koletti A, Thevenieau F, Koutinas AA, Nicaud JM & Aggelis G (2013) Importance of the methyl-citrate cycle on glycerol metabolism in the yeast Yarrowia lipolytica. J Biotechnol 168: 303-314.


Theerachat, M., Emond, S., Cambon, E., Bordes, F., Marty, A., Nicaud, J. M., Chulalaksananukul, W., Guieysse, D., Remaud-Simeon, M. and Morel, S. (2012). Engineering and production of laccase from Trametes versicolor in the yeast Yarrowia lipolytica. 
Bioresour Technol 125, 267-74. 

Gasmi, N., Lassoued, R., Ayed, A., Treton, B., Chevret, D., Nicaud, J. M. and Kallel, H. (2012). Production and characterization of human granulocyte-macrophage colony-stimulating factor (hGM-CSF) expressed in the oleaginous yeast Yarrowia lipolytica. Appl Microbiol Biotechnol 96, 89-101

Loira, N., Dulermo, T., Nicaud, J. M. and Sherman, D. J. (2012). A genome-scale metabolic model of the lipid-accumulating yeast Yarrowia lipolytica. BMC Syst Biol 6, 35. 

Nicaud, J. M. (2012). Yarrowia lipolytica. Yeast 29, 409-18.

Ogrydziak, D. M. and Nicaud, J. M. (2012). Characterization of Yarrowia lipolytica XPR2 multi-copy strains over-producing alkaline extracellular protease - a system for rapidly increasing secretory pathway cargo loads. FEMS Yeast Res 12, 938-48.

Beopoulos, A., Haddouche, R., Kabran, P., Dulermo, T., Chardot, T. and Nicaud, J. M. (2012). Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts. Appl Microbiol Biotechnol 93, 1523-37. 

Duquesne, S., Bordes, F., Fudalej, F., Nicaud, J. M. and Marty, A. (2012). The Yeast Yarrowia lipolytica as a Generic Tool for Molecular Evolution of Enzymes. Methods Mol Biol 861, 301-12.

Gaillardin, C., Neuveglise, C., Kerscher, S. and Nicaud, J. M. (2012). Mitochondrial genomes of yeasts of the Yarrowia clade. FEMS Yeast Res 12, 317-31.

Kabran, P., Rossignol, T., Gaillardin, C., Nicaud, J. M. and Neuveglise, C. (2012). Alternative Splicing Regulates Targeting of Malate Dehydrogenase in Yarrowia lipolytica. DNA Res 19, 231-44.