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I take part in the project of bacterial cell remodeling by viral infection in collaboration with Dr. Paulo Tavares. In this project, we are using bacteriophage SPP1 that infects the Gram-positive bacterium Bacillus subtilis. We aim to understand molecular and cellular mechanisms which are involving in viral genome replication factory and assembly of viral particles in bacterial cytoplasm. Here, I am using super-resolution microscopy to investigate spatial and/or dynamic localization of replication factory and viral particles in the cytoplasm of bacterium. For this purpose, I am performing 2D-3D Structured Illumination Microscopy and single-particle tracking Photoactivated Localization Microscopy.

2) Altinoglu I, Merrifield CJ, Yamaichi Y. Single molecule super-resolution imaging of bacterial cell pole proteins with high-throughput quantitative analysis pipeline. Sci Rep. 2019 Apr 30;9(1):6680. doi: 10.1038/s41598-019-43051-7.

1) Poidevin M, Sato M, Altinoglu I, Delaplace M, Sato C, Yamaichi Y. Mutation in ESBL Plasmid from Escherichia coli O104:H4 Leads Autoagglutination and Enhanced Plasmid Dissemination. Front Microbiol. 2018 Feb 2;9:130. doi: 10.3389/fmicb.2018.00130. eCollection 2018.

Experiences:

• 2015-2018: PhD research fellow. Institute for Integrative Biology of the Cell (I2BC), French National Centre for Scientific Research (CNRS), Gif-sur-Yvette, France.
• 2015: Master Intern. Laboratory of Biology and Applied Pharmacology (LBPA),D’Alembert Institute (IDA), ENS Cachan, Cachan, France.

Diplomas:

• 2018: PhD in Life and Health Sciences, Paris-Sud/Paris-Saclay University, Orsay, France.
  Thesis subject: Organization of bacterial cell pole in Vibrio cholerae.
• 2015: Molecular nano- and bio-photonics for telecommunications and biotechnologies (Monabiphot), ENS Cachan, Cachan, France.
  Thesis subject: Single cell fluorescent signal measurement of a gene expression by real time fluorescence microscopy