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 Liste des publications de l'équipe


Rolain T, Bernard E, Beaussart A, Degand H, Courtin P, Egge-Jacobsen W, Bron PA, Morsomme P, Kleerebezem M, Chapot-Chartier MP, Dufrêne YF, Hols P. (2013). O-glycosylation as a novel control mechanism of peptidoglycan hydrolase activity. J Biol Chem. 288(31):22233-47.

Regulski K, Courtin P, Kulakauskas S, Chapot-Chartier MP. (2013).A novel type of peptidoglycan-binding domain highly specific for amidated D-Asp cross-bridge, identified in Lactobacillus casei bacteriophage endolysins. J Biol Chem. 288(28):20416-26.

Peltier J, Courtin P, El Meouche I, Catel-Ferreira M, Chapot-Chartier MP, Lemee L, Pons JL. (2013). Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile. Microbiology. 159(Pt 7):1510-20.

Stockdale SR, Mahony J, Courtin P, Chapot-Chartier MP, van Pijkeren JP, Britton RA, Neve H, Heller KJ, Aideh B, Vogensen FK, van Sinderen D. (2013). The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization. J Biol Chem. 288(8):5581-90.

M.-P. Chapot-Chartier and M.-Y. Mistou. (2013) Aminopeptidase C (PepC) of lactic acid bacteria in Handbook of Proteolytic Enzymes (third edition) p 639-641 Eds A. Barrett, N. Rawlings and F. Woessner, Academic Press, London.


Bernard E, Rolain T, David B, André G, Dupres V, Dufrêne YF, Hallet B, Chapot-Chartier MP, Hols P. (2012).Dual role for the O-acetyltransferase OatA in peptidoglycan modification and control of cell septation in Lactobacillus plantarum. PLoS One. 7(10):e47893.

Rolain T, Bernard E, Courtin P, Bron PA, Kleerebezem M, Chapot-Chartier MP, Hols P. (2012). Identification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of Lactobacillus plantarum WCFS1. Microb Cell Fact. 11:137.

Benachour A, Ladjouzi R, Le Jeune A, Hébert L, Thorpe S, Courtin P, Chapot-Chartier MP, Prajsnar TK, Foster SJ, Mesnage S. (2012).The lysozyme-induced peptidoglycan N-acetylglucosamine deacetylase PgdA (EF1843) is required for Enterococcus faecalis virulence. J Bacteriol. 194(22):6066-73.

Caliot É, Dramsi S, Chapot-Chartier MP, Courtin P, Kulakauskas S, Péchoux C, Trieu-Cuot P, Mistou MY. (2012).Role of the Group B antigen of Streptococcus agalactiae: a peptidoglycan-anchored polysaccharide involved in cell wall biogenesis. PLoS Pathog. 8(6):e1002756.

Roces C, Courtin P, Kulakauskas S, Rodríguez A, Chapot-Chartier MP, Martínez B. (2012). Isolation of Lactococcus lactis mutants simultaneously resistant to the cell wall-active bacteriocin Lcn972, lysozyme, nisin, and bacteriophage c2. Appl Environ Microbiol. 78(12):4157-63.

Dramsi S, Dubrac S, Konto-Ghiorghi Y, Da Cunha V, Couvé E, Glaser P, Caliot E, Débarbouillé M, Bellais S, Trieu-Cuot P, Mistou MY. (2012). Rga, a RofA-like regulator, is the major transcriptional activator of the PI-2a pilus in Streptococcus agalactiae. Microb Drug Resist. 18(3):286-97.

Trémillon N, Morello E, Llull D, Mazmouz R, Gratadoux JJ, Guillot A, Chapot-Chartier MP, Monlezun L, Solé V, Ginisty H, Poquet I. (2012). PpiA, a surface PPIase of the cyclophilin family in Lactococcus lactis. PLoS One. 7(3):e33516.

Regulski K, Courtin P, Meyrand M, Claes IJ, Lebeer S, Vanderleyden J, Hols P, Guillot A, Chapot-Chartier MP. (2012). Analysis of the peptidoglycan hydrolase complement of Lactobacillus casei and characterization of the major γ-D-glutamyl-L-lysyl-endopeptidase. PLoS One. 7(2):e32301.

Claes IJ, Schoofs G, Regulski K, Courtin P, Chapot-Chartier MP, Rolain T, Hols P, von Ossowski I, Reunanen J, de Vos WM, Palva A, Vanderleyden J, De Keersmaecker SC, Lebeer S. (2012). Genetic and biochemical characterization of the cell wall hydrolase activity of the major secreted protein of Lactobacillus rhamnosus GG. PLoS One. 7(2):e31588.

van de Guchte M, Chaze T, Jan G, Mistou MY. (2012). Properties of probiotic bacteria explored by proteomic approaches. Curr Opin Microbiol. 15(3):381-9.


Bernard E, Rolain T, Courtin P, Hols P, Chapot-Chartier MP. (2011). Identification of the amidotransferase AsnB1 as being responsible for meso-diaminopimelic acid amidation in Lactobacillus plantarum peptidoglycan. J Bacteriol. 193(22):6323-30.

Habimana O, Guillier L, Kulakauskas S, Briandet R. Spatial competition with Lactococcus lactis in mixed-species continuous-flow biofilms inhibits Listeria monocytogenes growth. (2011). Biofouling. 27(9):1065-72.

Peltier J, Courtin P, El Meouche I, Lemée L, Chapot-Chartier MP, Pons JL. (2011). Clostridium difficile has an original peptidoglycan structure with a high level of N-acetylglucosamine deacetylation and mainly 3-3 cross-links. J Biol Chem. 286(33):29053-62.

Bernard E, Rolain T, Courtin P, Guillot A, Langella P, Hols P, Chapot-Chartier MP. (2011). Characterization of O-acetylation of N-acetylglucosamine: a novel structural variation of bacterial peptidoglycan. J Biol Chem. 286(27):23950-8.

Papasergi S, Brega S, Mistou MY, Firon A, Oxaran V, Dover R, Teti G, Shai Y, Trieu-Cuot P, Dramsi S. (2011). The GBS PI-2a pilus is required for virulence in mice neonates. PLoS One. 6(4):e18747.

Habimana O, Steenkeste K, Fontaine-Aupart MP, Bellon-Fontaine MN, Kulakauskas S, Briandet R. (2011). Diffusion of nanoparticles in biofilms is altered by bacterial cell wall hydrophobicity. Appl Environ Microbiol. 77(1):367-8.

M.-P. Chapot-Chartier, V. Monnet and L. de Vuyst (2011) Cell walls and exopolysaccharides of lactic acid bacteria. In: Thirty Years of Research on Lactic Acid Bacteria. Ed. M. Bingham, pp 37-59. 24 Media Labs, Rotterdam, Netherlands.


Andre G, Kulakauskas S, Chapot-Chartier MP, Navet B, Deghorain M, Bernard E, Hols P, Dufrêne YF. (2010). Nat Commun. 15;1:27.

Watterlot L, Meyrand M, Gaide N, Kharrat P, Blugeon S, Gratadoux JJ, Flores MJ, Langella P, Chapot-Chartier MP, Bermúdez-Humarán LG. (2010). Variations of N-acetylation level of peptidoglycan do not influence persistence of Lactococcus lactis in the gastrointestinal tract. Int J Food Microbiol. 144(1):29-34.

Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, Mistou MY, Khun H, Mechler C, Tardieux I, Trieu-Cuot P, Lecuit M, Poyart C. (2010). The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates. J Exp Med. 207(11):2313-22.

Deghorain M, Fontaine L, David B, Mainardi JL, Courtin P, Daniel R, Errington J, Sorokin A, Bolotin A, Chapot-Chartier MP, Hallet B, Hols P. (2010). Functional and morphological adaptation to peptidoglycan precursor alteration in Lactococcus lactis. J Biol Chem. 285(31):24003-13.

Hyyryläinen HL, Marciniak BC, Dahncke K, Pietiäinen M, Courtin P, Vitikainen M, Seppala R, Otto A, Becher D, Chapot-Chartier MP, Kuipers OP, Kontinen VP. (2010). Penicillin-binding protein folding is dependent on the PrsA peptidyl-prolyl cis-trans isomerase in Bacillus subtilis. Mol Microbiol. 77(1):108-27.

Camiade E, Peltier J, Bourgeois I, Couture-Tosi E, Courtin P, Antunes A, Chapot-Chartier MP, Dupuy B, Pons JL. (2010). Characterization of Acp, a peptidoglycan hydrolase of Clostridium perfringens with N-acetylglucosaminidase activity that is implicated in cell separation and stress-induced autolysis. J Bacteriol. 192(9):2373-84.

Chapot-Chartier MP, Vinogradov E, Sadovskaya I, Andre G, Mistou MY, Trieu-Cuot P, Furlan S, Bidnenko E, Courtin P, Péchoux C, Hols P, Dufrêne YF, Kulakauskas S. (2010). Cell surface of Lactococcus lactis is covered by a protective polysaccharide pellicle.J Biol Chem. 285(14):10464-71.

Martino A, Badell E, Abadie V, Balloy V, Chignard M, Mistou MY, Combadière B, Combadière C, Winter N. (2010). Mycobacterium bovis bacillus Calmette-Guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production. J. Immunol. 184(4):2038-47.

M.-P. Chapot-Chartier (2010) Bacterial autolysins. In : Prokaryotic Cell Wall Compounds - Structure and Biochemistry. Eds H. König, H. Claus and A. Varma, pp 383-406. SpringerVerlag.


Habimana O, Meyrand M, Meylheuc T, Kulakauskas S, Briandet R. (2009). Genetic features of resident biofilms determine attachment of Listeria monocytogenes. Appl Environ Microbiol. 75(24):7814-21.

Mistou MY, Dramsi S, Brega S, Poyart C, Trieu-Cuot P. (2009). Molecular dissection of the secA2 locus of group B Streptococcus reveals that glycosylation of the Srr1 LPXTG protein is required for full virulence. J Bacteriol. 191(13):4195-206.

Veiga P, Erkelenz M, Bernard E, Courtin P, Kulakauskas S, Chapot-Chartier MP. (2009). Identification of the asparagine synthase responsible for D-Asp amidation in the Lactococcus lactis peptidoglycan interpeptide crossbridge. J Bacteriol. 191(11):3752-7.

Layec S, Gérard J, Legué V, Chapot-Chartier MP, Courtin P, Borges F, Decaris B, Leblond-Bourget N. (2009). The CHAP domain of Cse functions as an endopeptidase that acts at mature septa to promote Streptococcus thermophilus cell separation. Mol Microbiol. 71(5):1205-17.

Bourgeois I, Camiade E, Biswas R, Courtin P, Gibert L, Götz F, Chapot-Chartier MP, Pons JL, Pestel-Caron M. (2009). Characterization of AtlL, a bifunctional autolysin of Staphylococcus lugdunensis with N-acetylglucosaminidase and N-acetylmuramoyl-l-alanine amidase activities. FEMS Microbiol Lett. 290(1):105-13.

Giaouris E, Chapot-Chartier MP, Briandet R. (2009). Surface physicochemical analysis of natural Lactococcus lactis strains reveals the existence of hydrophobic and low charged strains with altered adhesive properties. Int J Food Microbiol. 131(1):2-9.


Giaouris E, Briandet R, Meyrand M, Courtin P, Chapot-Chartier MP. (2008). Variations in the degree of D-Alanylation of teichoic acids in Lactococcus lactis alter resistance to cationic antimicrobials but have no effect on bacterial surface hydrophobicity and charge. Appl Environ Microbiol. 74(15):4764-7.

Roy K, Meyrand M, Corthier G, Monnet V, Mistou MY. (2008). Proteomic investigation of the adaptation of Lactococcus lactis to the mouse digestive tract. Proteomics. 8(8):1661-76.

Roy K, Anba J, Corthier G, Rigottier-Gois L, Monnet V, Mistou MY. (2008). Metabolic adaptation of Lactococcus lactis in the digestive tract: the example of response to lactose. J Mol Microbiol Biotechnol. 14(1-3):137-44.


Veiga, P., Bulbarela-Sampieri, C., Furlan, S., Maisons, A., Chapot-Chartier, M.-P., Erkelenz, M., Mervelet, P., Noirot, P., Frees, D., Kuipers, O., Kok, J., Gruss, A., Buist, G., and S. Kulakauskas. (2007) SpxB regulates O-acetylation dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis. J. Biol. Chem., 282: 19342-19354.

Meyrand, M., Boughammoura, A., Courtin, P.,Mézange, C., Guillot, A., and Chapot-Chartier, M.-P. (2007) Peptidoglycan N-acetylglucosamine deacetylation decreases autolysis in Lactococcus lactis. Microbiology, 153: 3275-3285.

Redko, Y., Courtin, P., Mézange, C., Huard, C. and Chapot-Chartier, M.-P. (2007) Lactococcus lactis gene yjgB encodes a gamma-D-glutaminyl-L-lysyl-endopeptidase which hydrolyses peptidoglycan. Appl. Environ. Microbiol., 18: 5825-5831.

Hébert, L. Courtin, P., Torelli, R., Sanguinetti, M., Chapot-Chartier, M.-P., Auffray, Y., Benachour, A. (2007) Enterococcus faecalis constitutes an unusual bacterial model in lysozyme resistance. Infect. and Immun., 75: 5390-5398.

Habimana, O., Le Goff, C., Juillard, V., Bellon-Fontaine, M.-N., Buist, G., Kulakauskas, S. and Briandet, R. (2007). Positive role of cell wall anchored proteinase PrtP in adhesion of lactococci, BMC Microbiol. 7: 36.

M.-P. Chapot-Chartier (2007) Autolysines des bactéries lactiques et mécanismes de lyse. In Bactéries lactiques : de la génétique aux levains. Eds G. Corrieu and F.-M. Luquet, Tec & Doc Lavoisier.