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Jean-Pierre Mothet - jeudi 15 septembre 2022 11h

jeudi 15 septembre 2022 11h - Micalis seminars

Jean-Pierre Mothet - jeudi 15 septembre 2022 11h
Emerging roles of d-amino acids in the brain and beyond: focus on d-serine

Emerging roles of d-amino acids in the brain and beyond: focus on d-serine

 Jean-Pierre Mothet

directeur de recherche au laboratoire LuMIn (CNRS, Gif-sur-Yvette).

Short abstract

The last two decades have witnessed remarkable advances in our understanding of the role of right-handed (d-) amino acids in Mammals and particularly in the nervous system: from the unknown, to known molecules with unknown functions, to potential central players in health and disease. d-Amino acids have emerged as an important class of signaling molecules. In particular, the exploration of the roles of d-serine in brain physiopathology is a vibrant field that has grown at an accelerating pace. During my talk I will show how the discovery of d-serine has dramatically transformed our vision of the mechanisms regulating excitatory neural circuitries and brain functioning and is now offering therapeutical promise for treating some of the major psychiatric disorders. I will also introduce new data from our lab that extends the physiological relevance of d-serine in circuits physiology by uncovering its control of cortical inhibitory synaptic networks through NMDA receptors and by showing that this unconventional messenger is also regulating gut physiology


Short CV

I am a neurobiologist and a Research Director at CNRS. I graduated from the University Pierre and Marie Curie, Paris, in 1996 working with Dr. Ladislav Tauc. Then, I pursued postdoctoral research with Pr Solomon H. Snyder at The Johns Hopkins School of Medicine (USA). There I first elucidated the functions and the synthesis pathway for a right-handed amino acid D-serine in the Mammalian brain. In 1999, I moved to the laboratory of Pr Jacopo Meldolesi (Italy) to study exocytosis of neurotransmitters. In 2018, I established my new team “Biophotonics and Synapse Physiopathology” at ENS Paris-Saclay which brings together biologists and optical physicists who are exploring the dynamics of synaptic networks in the healthy and diseased brain. My lab is notably internationally renowned for his studies on the regulation of NMDA receptors by their co-agonists. I served as the President of the French Club of Glial Cells (2012-2015) and was a council member of the European Society for Neurochemistry (2015-2021). I am a senior fellow of the University of Oxford (since 2018), a member of Academia Europaea (since 2020) and since 2021 a council member of the International Society for Neurochemistry. I also act as an academic member of the editorial board of Neuropharmacology, BMC Biology, PlosONE, Frontiers in Synaptic Neuroscience, Frontiers in Cellular Neuroscience and Neural Plasticity.

jeudi 15 septembre 2022 11h

Amphiteatre 440

invitée par Jasmina Vidic et Sandrine Auger