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Dernière mise à jour : Mai 2018

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Pole « Bacterial Adaptation and Pathogenesis »

The environment determines the balance between the organisms that inhabit it. The precise environmental conditions lead to competitions or synergies between organisms and ultimately favor the dominance of one or more species. A change in the environment can cause a profound shift in population balance. 

In the case of microorganisms, environmental changes can cause radical re-programming. Thus, a "harmless" microorganism in an environment can become "pathogenic", enventually producing toxic molecules under stress or stress conditions.

In the case of a microorganism present in humans or animals, the situation is even more complex: on the one hand, the microorganism modulates its expression to adapt to its host; on the other hand, it can reprogram the expression of its host to neutralize the defenses of the host and develop colonization and / or infection.

In response to the microorganism, the host modulates its own expression and may in turn modulate that of the microorganism.

Different mechanisms of "horizontal" transfer of genetic material may furthermore allow a microorganism to acquire functions favoring its adaptation to a given environment or more generally its adaptability, and possibly factors of virulence or pathogenesis.

The work of the "Bacterial Adaptation and Pathogenesis" cluster focuses on the molecular mechanisms implemented during these adaptive responses and these pathogenic processes, as well as on the genomic dynamics of opportunistic bacteria and yeasts of food origin that may have an impact on human and animal health.

The objectives of this work are the development of hazard identification tools, prevention strategies and the fight against pathogenic microorganisms of food origin.

The "ABP" cluster brings together 9 research teams whose work is organized around three main themes:

>Food microbial safety

>Host – pathogen interactions

>Adaptive mechanisms

The head of the pole "Bacterial Adaptation and Pathogenesis" is Romain Briandet.