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Dernière mise à jour : Mai 2018

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Dominique LE COQ

Dominique LE COQ

Dominique Le Coq is a CNRS researcher in the Micalis Institute. His main research interest consists in the study of regulation of genetic expression in Bacillus subtilis.

Dr. Le Coq obtained his Ph.D. in 1983 in the University Pierre et Marie Curie (Paris 6) after working on protein secretion and genetic regulation in B. subtilis, under the direction of Dr. Philippe Gay. He carried out postdoctoral studies on genetics of B. subtilis sporulation at the Scripps Clinic and Research Foundation, at La Jolla (California, USA) under the direction of Dr. James Hoch. He then took a position of “Chargé de Recherche” at CNRS at the Institut National Agronomique Paris-Grignon, now AgroParisTech, where several years of research were mainly focused on the mechanism of regulation by antiterminators of the BglG/SacY family in B. subtilis, and the link with the phosphotransferase system. He then has switched to more global studies, first by participating to the functional analysis of B. subtilis genes, and more recently to resarch on the regulation of the fluxes of the central carbon metabolism in this organism. He is also involved in the study of the formation of complex and structured thick biofilms by a non domesticated B. subtilis strain.

Dr. Le Coq has published a total of 37 articles in peered reviews.
Most recent publications:

1.      Caroline Pandin, Maud Darsonval, Camille Mayeur, Dominique Le Coq, Stéphane Aymerich, Romain Briandet. 2019. Biofilm formation and synthesis of antimicrobial compounds by the biocontrol agent Bacillus velezensis QST713 in Agaricus bisporus compost micromodel. Appl. Environ. Microbiol. doi: 10.1128/AEM.00327-19.

2.      Caroline Pandin, Régis Védie, Thierry Rousseau, Dominique Le Coq, Stéphane Aymerich, Romain Briandet. 2018. Dynamics of compost microbiota during the cultivation of Agaricus bisporus in the presence of Bacillus velezensis QST713 as a biocontrol agent against Trichoderma aggressivum. Biological Control 127:39-54.

3.      Caroline Pandin, Dominique Le Coq, Julien Deschamps, Régis Védie, Thierry Rousseau,  Stéphane Aymerich, Romain Briandet. 2018. Complete genome sequence of Bacillus velezensis QST713: A biocontrol agent that protects Agaricus bisporus crops against the green mould disease. J. Biotechnol. 278:10-19.

4.      Teddy Charbonnier, Dominique Le Coq, Stephen McGovern, Magali Calabre,Olivier Delumeau, Stéphane Aymerich and Matthieu Jules. 2017. Molecular and physiological logics of the pyruvate-induced response of a novel transporter in Bacillus subtilis. mBio 8:e00976-17.

5.      Caroline Pandin, Dominique Le Coq, Alexis Canette, Stéphane Aymerich and Romain Briandet. 2017. Should the biofilm mode of life be taken into consideration for microbial biocontrol agents ? Microbial  Biotechnology doi: 10.1111/1751-7915.12693

6.      Pilar Sanchez-Vizuete, Belen Orgaz, Stéphane Aymerich, Dominique Le Coq and Romain Briandet. 2015. Pathogens protection against the action of disinfectants in multispecies biofilms. Front. Microbiol. 6:705. doi: 10 3389/fmicb.2015.00705

7.      Pilar Sanchez-Vizuete, Dominique Le Coq, Arnaud Bridier, Jean-Marie Herry, Stéphane Aymerich, Romain Briandet. 2015. Identification of ypqP as a New Bacillus subtilis Biofilm Determinant That Mediates the Protection of Staphylococcus aureus against Antimicrobial Agents in Mixed-Species Communities. Appl. Environ. Microbiol. 81:109-118

8.      Pilar Sanchez-Vizuete, Kosei Tanaka, Arnaud Bridier, Yusuke Shirae, Ken-ichi Yoshida, Théodore Bouchez, Stéphane Aymerich, Romain Briandet , Dominique Le Coq. 2014. Genome Sequences of Two Nondomesticated Bacillus subtilis Strains Able To Form Thick Biofilms on Submerged Surfaces. Genome Announcements 2(5):e00946-14

9.      Matthew L. Ferguson , Dominique Le Coq , Matthieu Jules , Stéphane Aymerich , Ovidiu Radulescu , Declerck Nathalie and Catherine A Royer. 2012. Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states, Proc. Natl. Acad. Sci. USA 109:155-160.

10.  Frederik M. Meyer, Matthieu Jules, Felix M. P. Mehne, Dominique Le Coq, Jens J. Landmann, Boris Görke, Stéphane Aymerich, and Jörg Stülke. 2011. Malate-Mediated Carbon Catabolite Repression in Bacillus subtilis Involves the HPrK/CcpA Pathway. J. Bacteriol. 193:6939-6949.

11.  Matthew L. Ferguson, Dominique Le Coq,  Matthieu Jules, Stéphane Aymerich, Nathalie Declerck, and Catherine A. Royer. 2011. Absolute Quantification of Gene Expression in Individual Bacterial Cells Using Two Photon Fluctuation Microscopy. Anal. Biochem. 419:250-259

12.  Sebastian Hübner, Nathalie Declerck, Christine Diethmaier,  Dominique Le Coq,  Stéphane Aymerich and Jörg Stülke. 2011. Prevention of cross-talk in conserved regulatory systems: identification of specificity determinants in RNA-binding anti-termination proteins of the BglG family. Nucl. Acids Res. doi:10.1093/nar/gkr021. Nucl. Acids Res. 39:4360-4372

13.  Arnaud Bridier, Dominique Le Coq, Florence Dubois-Brissonnet, Vincent Thomas, Stéphane Aymerich and Romain Briandet. 2011. The spatial architecture of Bacillus subtilis biofilms deciphered using a surface-associated model and in-situ imaging. PLoS ONE 6(1):e16177. doi:10.1371/journal.pone.0016177.