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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Micalis

3-years PhD Position in Microbiology and Proteomics at INRAE, Université Paris Saclay, France. In the context of Marie Skłodowska-Curie Innovative Training Networks Action (MSCA)

PEST-BIN is a MSCA project funded by the European Commission, Horizon 2020 Program. Commencing its activities in 2021, the Network will provide PhD training to 15 Early Stage Researchers (ESRs) for 3 years.

3-years PhD Position in Microbiology and Proteomics. Paris area, France
© Hélène Bierne
Context. Antibiotic resistance has been named as one of the greatest threats to global health by the World Health Organization. There are increasing numbers of bacterial infections not responding to known antibiotics. The humanity needs to pioneer disruptive technologies to re-gain the upper hand. To do so, PEST-BIN mobilizes six universities, three research institutes, one hospital and five private companies with one common mission: to pioneer novel technologies to fight bacterial infections. All PEST-BIN PhD students will be trained in an intersectoral environment – experiencing a tight collaboration among academia, healthcare and the private sector.

PhD Project Description. The bacterial pathogen Listeria monocytogenes is the agent of listeriosis, one of the most dangerous food-borne diseases. Listeria contamination is essentially detected by classical microbiology tests based on enrichment steps, thus relying on the cultivability of bacteria. However, both extracellular and intracellular Listeria are able to enter a dormant state called VBNC, characterized by loss of bacterial growth in conventional culturing media. Although undetectable, VBNC bacteria maintain their pathogenic potential, thus representing a risk for human and animal health. By applying cutting edge techniques (RNA sequencing and quantitative proteomics), the project aims at defining the physiological markers of VBNC Listeria and providing fundamental knowledge on asymptomatic bacterial infections. This One Health project also intends to develop tools for the detection of silent VBNC Listeria in food, human and animal samples. We are seeking a doctoral candidate with great interest for host-pathogen interaction. The project is at the interface of two teams: Epigenetics and Cellular Microbiology team (https://www.micalis.fr/micalis_eng/Poles-and-teams/Pole-Bacterial-Adaptation-and-Pathogenesis/Epigenetics-and-Cellular-Microbiology-Helene-Bierne) and PAPPSO platform (http://pappso.inra.fr) of the MICALIS institute. The student will use Microbiology, Molecular and Cell Biology techniques and high-resolution Mass Spectrometry.

  • Skills details
  • - Microbiology, Biochemistry, Molecular Biology.
  • - Skills in Bioinformatics and notions of Proteomics would be an asset
  • - Team spirit; enthusiasm in doing research in multidisciplinary environments and at the interface of two teams
  • - Ability to understand and express in both written and spoken English at a high level

Benefits and salary. The successful candidate will receive an attractive salary in accordance with the MSCA regulations for Early Stage Researchers (http://ec.europa.eu/research/mariecurieactions/). The exact salary will be confirmed upon appointment and is dependent on the country correction factor (to allow for the difference in cost of living in different EU Member States). The salary includes a living allowance, a mobility allowance and a family allowance (if already married) for 36 months. All students will have a personal career development plan and benefit from continuing education, secondments and training/networking events within PEST-BIN. They will be guided by an academic and non-academic supervisor, experiencing a truly intersectoral working environment.

Eligibility. Applicants are required to undertake transnational mobility when taking up their appointment. At the time of recruitment, the candidate must not have resided or carried out his/her main activity in France for more than 12 months in the 3 years immediately prior to the date of appointment. Applicants must hold a diploma granting access to PhD studies (typically a MSc degree).

How to apply. Please submit your application in English, including a cover letter describing your motivations, a curriculum vitae with ID photo, and two reference letters, within a single PDF document, and state "PhD-ITN application" in the subject of your email.

 Applications should be sent before January 15th, 2021 by email to: helene.bierne@inrae.fr and celine.henry@inrae.fr