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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Christina Nielsen-Leroux

PhD, Research Director (DR2), INRAE

- Contact me :

E-mail: Christina Nielsen-Leroux

Téléphone: +33 (0)1 34 65 21 01

Cursus

- 1989: Agronomist (R.V.A.U.) of Copenhagen, Denmark.

- 1994: Ph.D. University of Pierre et Marie Curie, ParisVI,

- 2006: HDR (Habilitation to supervise research).

Positions

- 1987: MASTER trainee Lab. entomology at C.I.R.A.D.

- 1989: Research Assistant dept. Biocontrol, NOVO-NORDISK A/S

- 1990-1994: Ph.D. student at Pasteur Institute

- 1994-1995: Post. Doc. at Pasteur Institute (Danida funded project)

- 1995-1997: Research assistant at Pasteur Institute.

- 1998-2006: Research Scientist at Pasteur Institute and INRA (2002-)

- 2007 to present: Permanent Position at INRA, Senior Researcher-DR2.

Other activities/responsabilities

- Supervision of 4 Post-docts, 4 doctorants, 4 Masters. Two technicians

- 35 publications (International)

- Participation in 38 conferences, 15 as invited speaker

- Edition of book: Entomopathogenic bacteria: from laboratory to field application

- Organisation of two symposia: SIP (Society Invertebrate Pathology) 2002, 2005 and 2008.

- Member of Jury & competitions: 8

- Project (WHO, ANR and others) responsible (5).

Selected publications from the past five years

- Vörös A, Simm R, Slamti L, McKay MJ, Hegna IK, Nielsen-LeRoux C, Hassan KA, Paulsen IT, Lereclus D, Okstad OA, Molloy MP, Kolstø AB. (2014). SecDF as part of the Sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins. PLoS One. 1; 9(8): e103326. doi: 10.1371/journal.pone.0103326.

- Segond D, Abi Khalil E, Buisson C, Daou N, Kallassy M, Lereclus D, Arosio P, Bou-Abdallah F, Nielsen Le Roux C. (2014). Iron acquisition in Bacillus cereus: the roles of IlsA and bacillibactin in exogenous ferritin iron mobilization. PLoS Pathog. 10(2):e1003935. doi: 10.1371/journal.ppat.1003935

- Nielsen-Leroux C, Gaudriault S, Ramarao N, Lereclus D, Givaudan A. (2012) How the insect pathogen bacteria Bacillus thuringiensis and Xenorhabdus/Photorhabdus occupy their hosts. Curr Opin Microbiol. 15(3): 220-231.

- Song F, Peng Q, Brillard J, Buisson C, de Been M, Abee T, Broussolle V, Huang D, Zhang J, Lereclus D, Nielsen-Leroux C. (2012). A multicomponent sugar phosphate sensor system specifically induced in Bacillus cereus during infection of the insect gut. FASEB J. 26(8): 3336-3350.

- Stenfors Arnesen L, Granum PE, Buisson C, Bohlin J, Nielsen-LeRoux C. (2011) .Using an insect model to assess correlation between temperature and viruelnce in Bacillus weihenstephanensis and Bacillus cereus. FEMS Microbiol Lett.317(2): 196-202.

- Raymond B, Johnston PR, Nielsen–LeRoux C, Lereclus D, Crickmore N. (2010). Bacillus thuringiensis: an impotent pathogen? Trends Microbiol 18(5): 189-194.

- Fedhila S., Buisson C., Dussurget O., Serror P. Glomski I.J. , Liehl P., Lereclus D., Nielsen-LeRoux C. (2010). Comparative analysis of the virulence of invertebrate and mammalian pathogenic bacteria in the oral insect infection model Galleria mellonella. J. Invertebr. Pathol. 103(1): 24-9.

- Daou N, Buisson C, Gohar M, Vidic J, Bierne H, Kallassy M, Lereclus D, Nielsen-LeRoux C. (2009). IlsA, a unique surface protein of Bacillus cereus required for iron acquisition from heme, hemoglobin and ferritin." PLoS Pathog 5(11): e1000675.

- Abi Khattar Z, Kallassy M, Rejasse A, Destoumieux D, Escoubas JM, Sanchis V, Lereclus, Givaudan A, Nielsen-Leroux C, Gaudriault S. (2009). "The dlt operon of Bacillus cereus is required for resistance to cationic antimicrobial peptides and for virulence in insects." J Bacteriol 191(22): 7063-7073.

- Fedhila S, Daou N, Lereclus D, Nielsen-LeRoux C. (2006) Identification of Bacillus cereus internalin and other candidate virulence gene specifically induced during infection in insects. Mol. Microbiol. 62: 339-355.