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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Alexandre Bolotine

Alexandre Bolotine
PhD, Research Engineer (IR1), INRA

- Contact me :

E.mail: Alexandre Bolotine

Téléphone: +33 (0)1 34 65 25 33



1980-1983: PhD student in Genetics of Microorganisms, VNII Genetika, Moscow

1985: PhD Thesis in Molecular Biology

1983-1993: Researcher, VNII Genetika, Moscow

1993-1994: Post-doctoral, Université Henry Poincaré, Institut de Génétique et Microbiologie, Nancy

1994-1995: Post-doctoral, Université Paris-Sud, Institut de Génétique et Microbiologie, Orsay

1995-2001: Post-doctoral, Génétique Microbienne, INRA

2001-present: Research Engineer, Génétique Microbienne, INRA


Bio-informatic experiences

Exploitation systems: Solaris 7, Windows, Linux.

Programming languages: Perl (~3000 code lines), awk (>10000 code lines), HTML

Applications: NGS (next generation sequencing), sequence data assembling (MAQ, SOAP, CORONA, STADEN, PHRED, PHRAP, CONSED), data analysis (GCG and others)

Developing of specialized Intranet sites (including executable software)

Scientific training

3 PhD students, 2 post-doctoral fellows and young scientists and several undergraduate students



Coordinator or participant of several bacterial sequencing projects (L. lactis, industrial Bacilli, S. thermophilus, industrial dairy bacteria).

Recent selected publications

(In total 45 publications in international journals, 3 publications in books, 3 patents, 5 oral presentations at international conferences)

- Auger S, Galleron N, Ségurens B, Dossat C, Bolotin A, Wincker P, Sorokin A. (2012).Complete genome sequence of the highly hemolytic strain Bacillus cereus F837/76. J. Bacteriol. 194(6):1630.

- Bolotin, A., Quinquis, B., Ehrlich, S.D., Sorokin, A. (2012). Complete genome sequence of Lactococcus lactis subsp. cremoris A76. J. Bacteriol. 194(5):1241-1242.
- Chervaux, C., Grimaldi, C., Bolotin, A., Quinquis, B., Legrain-Raspaud, S., Van Hylckama Vlieg, J.E., Denariaz, G., Smokvina, T. (2011).Genome sequence of the probiotic strain Bifidobacterium animalis subps. lactis CNCM I-2494. J. Bacteriol. 193, 55600.

- Deghorain, M., L. Fontaine, B. David, J. L. Mainardi, P. Courtin, R. Daniel, J. Errington, A. Sorokin, A. Bolotin, M. P. Chapot-Chartier, B. Hallet, and P. Hols. (2010). Functional and morphological adaptation to peptidoglycan precursor alteration in Lactococcus lactis. J Biol Chem 285:24003-13.

- Delorme, C., C. Bartholini, A. Bolotine, S. D. Ehrlich, and P. Renault. (2010). Emergence of a cell wall protease in the Streptococcus thermophilus population. Appl Environ Microbiol 76:451-60.

- Ibrahim, M., P. Nicolas, P. Bessieres, A. Bolotin, V. Monnet, and R. Gardan. (2007). A genome-wide survey of short coding sequences in streptococci. Microbiology 153:3631-44.

- Van de Guchte, M., S. Penaud, C. Grimaldi, V. Barbe, K. Bryson, P. Nicolas, C. Robert, S. Oztas, S. Mangenot, A. Couloux, V. Loux, R. Dervyn, R. Bossy, A. Bolotin, J. M. Batto, T. Walunas, J. F. Gibrat, P. Bessieres, J. Weissenbach, S. D. Ehrlich, and E. Maguin. (2006). The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution. Proc Natl Acad Sci U S A 103:9274-9.

- Bolotin A, Quinquis B, Renault P, Sorokin A, Ehrlich SD, Kulakauskas S, Lapidus A, Goltsman E, Mazur M, Pusch GD, Fonstein M, Overbeek R, Kyprides N, Purnelle B, Prozzi D, Ngui K, Masuy D, Hancy F, Burteau S, Boutry M, Delcour J, Goffeau A, Hols P (2004), Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus. Nature Biotechnology 22 (12): 1554-1558.