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Crystallographic snapshots of a B12-dependent radical SAM methyltransferase. Fyfe CD, Bernardo-García N, Fradale L, Grimaldi S, Guillot A, Brewee C, Chavas LMG, Legrand P, Benjdia A, Berteau O. Nature. 2022 Feb;602(7896):336-342. doi: 10.1038/s41586-021-04355-9.

Exploring the Biosynthetic Potential of TsrM, a B12 -dependent Radical SAM Methyltransferase Catalyzing Non-radical Reactions. Soualmia F, Guillot A, Sabat N, Brewee C, Kubiak X, Haumann M, Guinchard X, Benjdia A, Berteau O. Chemistry. 2022 Jun 1;28(31):e202200627. doi: 10.1002/chem.202200627.

Radical SAM Enzymes and Ribosomally-Synthesized and Post-translationally Modified Peptides: A Growing Importance in the Microbiomes. Benjdia A, Berteau O. Front Chem. 2021 Jul 19;9:678068. doi: 10.3389/fchem.2021.678068. 

The Epipeptide Biosynthesis Locus epeXEPAB Is Widely Distributed in Firmicutes and Triggers Intrinsic Cell Envelope Stress. Popp PF, Friebel L, Benjdia A, Guillot A, Berteau O, Mascher T. Microb Physiol. 2021;31(3):306-318. doi: 10.1159/000516750. 

Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes. Balty C, Guillot A, Fradale L, Brewee C, Lefranc B, Herrero C, Sandström C, Leprince J, Berteau O, Benjdia A. J Biol Chem. 2020 Dec 4;295(49):16665-16677. doi: 10.1074/jbc.RA120.015371.

Gold-Catalyzed Spirocyclization Reactions of N-Propargyl Tryptamines and Tryptophans in Aqueous Media. Sabat N, Soualmia F, Retailleau P, Benjdia A, Berteau O, Guinchard X. Org Lett. 2020 Jun 5;22(11):4344-4349. doi: 10.1021/acs.orglett.0c01370. 

The Epipeptide YydF Intrinsically Triggers the Cell Envelope Stress Response of Bacillus subtilis and Causes Severe Membrane Perturbations. Popp PF, Benjdia A, Strahl H, Berteau O, Mascher T. Front Microbiol. 2020 Feb 11;11:151. doi: 10.3389/fmicb.2020.00151.

Ruminococcin C, an anti-clostridial sactipeptide produced by a prominent member of the human microbiota Ruminococcus gnavus. Balty C, Guillot A, Fradale L, Brewee C, Boulay M, Kubiak X, Benjdia A, Berteau O. J Biol Chem. 2019 Oct 4;294(40):14512-14525. doi: 10.1074/jbc.RA119.009416.

Mechanistic Investigations of PoyD, a Radical S-Adenosyl-l-methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis. Parent A, Benjdia A, Guillot A, Kubiak X, Balty C, Lefranc B, Leprince J, Berteau O. J Am Chem Soc. 2018 Feb 21;140(7):2469-2477. doi: 10.1021/jacs.7b08402.

Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs). Benjdia A, Balty C, Berteau O. Front Chem. 2017 Nov 8;5:87. doi: 10.3389/fchem.2017.00087.

Post-translational modification of ribosomally synthesized peptides by a radical SAM epimerase in Bacillus subtilis. Benjdia A, Guillot A, Ruffié P, Leprince J, Berteau O. Nature Chemistry 2017 Jul;9(7):698-707. doi: 10.1038/nchem.2714.

Insights into the catalysis of a lysine-tryptophan bond in bacterial peptides by a SPASM domain radical S-adenosylmethionine (SAM) peptide cyclase. Benjdia A, Decamps L, Guillot A, Kubiak X, Ruffié P, Sandström C, Berteau O. J Biol Chem. 2017 Jun 30;292(26):10835-10844. doi: 10.1074/jbc.M117.783464.

DNA Repair by the Radical SAM Enzyme Spore Photoproduct Lyase: From Biochemistry to Structural Investigations. Berteau O, Benjdia A. Photochem Photobiol. 2017 Jan;93(1):67-77. doi: 10.1111/php.12702.

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis. Parent A, Guillot A, Benjdia A, Chartier G, Leprince J, Berteau O. J Am Chem Soc. 2016 Dec 7;138(48):15515-15518. doi: 10.1021/jacs.6b06697.

Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE. Rohac R, Amara P, Benjdia A, Martin L, Ruffié P, Favier A, Berteau O, Mouesca JM, Fontecilla-Camps JC, Nicolet Y. Nature Chemistry. 2016 May;8(5):491-500. doi: 10.1038/nchem.2490.

Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis. Benjdia A, Guillot A, Lefranc B, Vaudry H, Leprince J, Berteau O. Chem Commun (Camb). 2016 May 7;52(37):6249-6252. doi: 10.1039/c6cc01317a.

Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota. Benjdia A, Berteau O. Biochem Soc Trans. 2016 Feb;44(1):109-15. doi: 10.1042/BST20150191.

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction. Benjdia A, Pierre S, Gherasim C, Guillot A, Carmona M, Amara P, Banerjee R, Berteau O. Nat Commun. 2015 Oct 12;6:8377. doi: 10.1038/ncomms9377.

Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase. Benjdia A, Heil K, Winkler A, Carell T, Schlichting I. Chem Commun (Camb). 2014 Nov 25;50(91):14201-4. doi: 10.1039/c4cc05158k.

Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. Ulmer JE, Vilén EM, Namburi RB, Benjdia A, Beneteau J, Malleron A, Bonnaffé D, Driguez PA, Descroix K, Lassalle G, Le Narvor C, Sandström C, Spillmann D, Berteau O. J Biol Chem. 2014 Aug 29;289(35):24289-303. doi: 10.1074/jbc.M114.573303.

A radical transfer pathway in spore photoproduct lyase. Yang L, Nelson RS, Benjdia A, Lin G, Telser J, Stoll S, Schlichting I, Li L.Yang L, et al. Biochemistry. 2013 May 7;52(18):3041-50. doi: 10.1021/bi3016247.

DNA photolyases and SP lyase: structure and mechanism of light-dependent and independent DNA lyases. Benjdia A. Curr Opin Struct Biol. 2012 Dec;22(6):711-20. doi: 10.1016/

Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate. Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O. J Am Chem Soc. 2012 Nov 7;134(44):18173-6. doi: 10.1021/ja307762b

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes. Pierre S, Guillot A, Benjdia A, Sandström C, Langella P, Berteau O. Nat Chem Biol. 2012 Dec;8(12):957-9. doi: 10.1038/nchembio.1091.

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. Benjdia A, Heil K, Barends TR, Carell T, Schlichting I. Nucleic Acids Res. 2012 Oct;40(18):9308-18. doi: 10.1093/nar/gks603.

Chondroitin-4-O-sulfatase from Bacteroides thetaiotaomicron: exploration of the substrate specificity. Malleron A, Benjdia A, Berteau O, Le Narvor C. Carbohydr Res. 2012 May 15;353:96-9. doi: 10.1016/j.carres.2012.03.033.

Sulfatases and a radical S-adenosyl-L-methionine (AdoMet) enzyme are key for mucosal foraging and fitness of the prominent human gut symbiont, Bacteroides thetaiotaomicron. Benjdia A, Martens EC, Gordon JI, Berteau O. J Biol Chem. 2011 Jul 22;286(29):25973-82. doi: 10.1074/jbc.M111.228841.