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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Projects and Collaborations

International:

“GEMMA (Genome, Environment, Microbiome & Metabolome in Autism)”, An integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectrum Disorders, Research & Innovation Action, H2020-BHC-03-2018 (2018-2022).

Coord: European Biomedical Research Institute Salerno, Italy

“A sound microbiota in a sound body through apolipoprotein A-I and HDL: from mouse models to humans”. European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL) ERA-Net Cofund “Interrelation of the INtesTInal MICrobiome, Diet and Health” (HDHL-INTIMIC) (2018-2021).

Coord: G. Chiesa, University of Milan, Italy

“Faecal microbiome as determinant of the effect of diet on colorectal-cancer risk: comparison of meat based versus pesco-vegetarian diets”. European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL) ERA-Net Cofund “Interrelation of the INtesTInal MICrobiome, Diet and Health” (HDHL-INTIMIC) (2018-2020).

Coord: C De Filippo, National Research Council, Italy

"Effect of indole production by the gut microbiota on the neurobiology of anxiety and mood disorders", Hubert Curien Partnership, France-China Programme "Xu-GuangQi" (2018)

“Functions and metabolic adaptation of dominant gut bacteria of the family Coriobacteriaceae in the context of host lipid metabolism“. ANR-DFG, French-German bilateral project (2014-2017).

Coord. T. Clavel, TUM, Germany ; P. Lepage, Micalis)

“Indole production by gut bacteria and neurovegetative symptoms of depression”: US Brain and Behavior Research Foundation (2016-2018)

“Understanding the mechanisms of obesity development in germfree mice induced by LPS-producing bacteria isolated from obese human gut”, collaboration with Prof L. Zhao, University of Shanghai, China. (2013-2016)National

National

. ANR MAMIPROOFI "Programmation de l'appétit chez la descendance par les microbiotes de mères obèses"I (2016-2019)

Coord. : P. Parnet, INRA, Nantes

. ANR FunAMetaGen "Analyse fonctionnelle d’espèces métagénomiques présélectionnées comme étant potentiellement prédictives de la progression de la NAFLD, pour une meilleure prise en charge médicale des patients", Appel à projet générique 2015 (2015-2019)

Coord. L. Chêne, Entérome company

. ANR ObeMAIT : "Rôle des cellules T invariantes associées aux muqueuses (MAIT) dans l’obésité chez l’homme et dans les modèles animaux", Appel à projet générique 2014 (2014-2018)

Coord. A. Lehuen, INSERM 1016, Paris

. "Influence de la structure des aliments laitiers sur le devenir digestif du tryptophane : production de métabolites neuro-actifs par le microbiote intestinal" : INRA (Départements CEPIA, MICA et ALIMH, 2016-2018)

. "Métabolisme du tryptophane par le microbiote intestinal : impact sur la physiopathologie de la dépression" (Tryptophan metabolism by gut bacteria : role in the pathophysiology of depression). Fondation de France, (2017-2018)

. "Mise en place d’un modèle de rat obèse induit par une alimentation riche en lipides pour identifier des propriétés anti-inflammatoires d’un commensal humain, Streptococcus salivarius". Prix de recherche du Groupe de Réflexion sur l’Obésité et le Surpoids (GROS) 2015

. "Rôle de la flore et de l'homéostasie intestinale dans la médiation des effets délétères du fructose" (Prix Nutrition de l’Institut Benjamin Delessert 2014)

. Prix FRM “Intestinal microbiota and genesis of alcoholic hepatitis”, (2011-2013)

R&D contracts with the industry

. "Etude des effets antidépresseurs de probiotiques", Pileje company (2017-2018)

. "Role of the gut microbiota in the pathophysiology of mood disorders: fecal microbiota transplantation experiments from human patients to laboratory rodent": Enterome Company (2015)

. "Interaction matrice lipidique des formules infantiles, et biologie intestinale, conséquences sur le métabolisme glucidique de l’adulte ", Lactalis company ( 2014-2017)

Coord : I. Luron (ADNC UR1341, Rennes)

. "Sélection in vivo d’ingrédients innovants à effets prébiotiques", Pileje company (2015-2016)