Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal

Home page


Biologie Intégrative du Métabolisme Lipidique

logo bimlip

 Biologie Intégrative du Métabolisme Lipidique microbien

Responsables : Jean-Marc Nicaud

Jean-Marc Nicaud



The exhaustion of "fossil fuels" and "food for all" are among the major concerns of our time. In this context, the search for renewable energy and alternatives to petrochemicals without competing with food becomes a priority. The use of microorganisms such as bacteria, algae or fungi for the production of biofuels (bio-lipids) and high value-added lipid derivatives from renewable resources is actually promising.

The BIMLip team "Integrative Biology of Lipid Metabolism" undertakes a fundamental approach to systemic biology and genetic engineering of lipid metabolism of oleaginous yeasts and in particular Yarrowia lipolytica. The team exploits the knowledge acquired for applications in biofuels, biolipids, bioplastics and for white chemistry. It also uses the gene expression and amplification systems it has developed for the production of enzymes for biotechnological and medical use.

The work of the BIMLip team revolves around 3 major axes:


Axis 1:  Lipids metabolism

This first axis aims to decipher the lipid metabolism based on an integrative biology approach by focusing on the regulatory mechanisms, the analysis of enzymes involved in the transport, storage and activation of fatty acids in the cell.

This axis also integrates the study of the enzymes involved in the use of sugar transport and storage and the importance of competition between the carbon utilization pathways in Y. lipolytica.


metabolisme et activation

Axis 2:  Synthetic Biology

The second axis focuses on synthetic biology, through the development of a regulatory inference network and a metabolic model for Y. lipolytica. In parallel, we are developing a set of powerful cloning and genomic editing tools (CRISPR / Cas9, Goldengate, Gateway), as well as new inducible synthetic promoters whose strength is flexible for a fine control of gene expression.




Axis 3:  Valorization

The third axis focuses on the valorization of our research, in order to develop efficient cell factories for the production of enzymes, lipids, unusual lipid derivatives and for the production of Chassies strains for the production of compounds with high added value, exploiting the knowledge acquired on lipid metabolism and in the fields of synthetic biology.


carotenoid et odd chain

L'équipe BIMLip 2018!


equipe bimlip-2018small


European Project H2020: CHASSY



Investissement d'Avenir PIVERT


IDI Paris-Saclay-2016, Initiative Doctorale Interdisciplinaire