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Genetic Controls in Bacterial Systems / Stéphane Aymerich & Mathieu Jules

Genetic Controls in Bacterial Systems

Steph

Aymerich and Jules Lab.

Directors: Stéphane Aymerichand Matthieu Jules

MaPhoto

The team comprises several distinct research activities, one of which is promoted by an independent scientific group (SyBER). However, the team's research activities have all in common:

  • a general research theme of functionally understanding Gram-positive bacteria (in particular the model bacterium Bacillus subtilis);
  • the use of interdisciplinary approaches through collaborations with mathematical modeling, biostatistics, bioinformatics and biophysicist teams;
  • the development of new methodologies and the sharing of data and biological materials.

These research activities also have distinct scientific identities:

Systems Biology for bacterial Engineering and Redesign -SyBER group led by Pr. Matthieu Jules

The SyBER group aims at understanding the overall functionning of the fundamental cellular processes (replication, transcription and translation), from single-cell to cell population. Members of SyBER apply quantitative and systemic experimental approaches in combination with mathematical modeling and exploit the newly acquired knowledge using synthetic biology approaches (genome engineering, metabolic engineering, etc.) to:

  • rationally modify B. subtilis, and at midterm Escherichia coli, to generate efficient cell factories (for the production of proteins and metabolites of interest).
  • conceive synthetic biological systems possessing novel functions, i.e. not found in nature (new metabolic activities, biosensors, etc.).

Bacterial adaptation to changing growth conditions

Competences and expertise in genetics of Bacillaceae also serve to:

  • understand in an integrated manner the systemic functioning of a bacterial cell to clarify the overall principles and mechanisms involved during B. subtilis adaptation in response to changing environments.
  • decipherthe molecular mechanisms and interactions governing single and multi-species biofilms, including either B. subtilis or the opportunistic pathogen Bacillus cereus.