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Micalis

Systems Biology for bacterial Engineering and Redesign

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Head: Pr. Matthieu Jules

 

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Systems Biology provides a multidisciplinary and multi-scale understanding of the overall functioning of living organisms, from regulatory and metabolic networks to the synergistic interaction of each of their components. Synthetic Biology combines two complementary approaches: the deconstruction of systems and complex biological phenomena into simple elements and the design of new biological systems from these well-characterized elements. Systems Biology therefore provides principles to explain the logic of living organisms while Synthetic Biology tests and exploits these principles by applying engineering methodologies. These two disciplines are in constant interaction and feed each other to develop concepts and tools for biotechnology.

The SyBER group aims at understanding the overall functionning of the fundamental cellular processes (replication, transcription and translation), from single-cell to cell population. Members of SyBER apply quantitative and systemic experimental approaches in combination with mathematical modeling and exploit the newly acquired knowledge using synthetic biology approaches (genome engineering, metabolic engineering, etc.) to:

  • rationally modify B. subtilis, and at midterm Escherichia coli, to generate efficient cell factories (for the production of proteins and metabolites of interest).
  • conceive synthetic biological systems possessing novel functions, i.e. not found in nature (new metabolic activities, biosensors, etc.).

Illustrated below the strategy and research activities of SyBER:

SyBER_activities

Main collaborators

  • Dr. Vincent Fromion (Mathematical modeling, MaIAGE, INRA, Jouy-en-Josas, France)
  • Dr. Pierre Nicolas (Statistics & Bioinformatics, MaIAGE, INRA, Jouy-en-Josas, France)
  • Dr. Emmanuelle Maguin (Ife, MICALIS, INRA, Jouy-en-Josas, France)
  • Dr. Jérôme Bonnet (Synthetic microbiology, CBS, Montpellier, France)
  • Dr. Uwe Sauer (Metabolomics and fluxomics, ETH, Zürich, Suisse)
  • Dr. Magali Remaud-Simeon and Dr. Gabrielle Veronèse (Enzyme engineering, LISBP, INRA/INSA/CNRS, Toulouse, France)
  • Dr. Philippe Noirot (Biosciences Division, Argonne, Chicago, USA)
  • Dr. Christopher Henry (Mathematics and Computer Science, Argonne, Chicago, USA)
  • Dr. Ulrike Mäder (Functional genomics, EMAU, Greifswald, Germany)
  • etc.

Fundings

INRA
ParisSaclay
toulouse-white-biotechnology
BaSynthec
ANR
APT
ITN
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See also

The European integrated projects, BaSysBio (Bacillus Systems Biology) and BaSynthec (Bacterial Synthetic minimal genomes for biotechnology);

The French national network on Systems and Synthetic Biology (BioSynSys);

The institute of modeling of living systems (IMSV headed by MaIAGE and V. Fromion, IDEX Paris-Saclay)

Follow us on Twitter: @SyBER_Micalis