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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

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Matthieu Jules

Microbial Molecular Systems

Matthieu Jules
Professor / AgroParisTech

Matthieu Jules is Professor at AgroParisTech; he is the co-leader of the team and the leader of the SyBER group. His research focuses both on the central carbon metabolism and its regulations and on the functioning of the major cellular processes (transcription and translation) with emphasis on systemic approaches and mathematical modeling (visit his website).

Dr. Jules obtained his Ph.D in 2004 in the Department of “Engineering of Biological Systems and Process” at the National Institute of Applied Sciences (INSA, Toulouse) under the direction of Professor Jean-Marie François. In 2004 he accepted a one-year research position with part-time teaching duties under the direction of Dr. Jean-Luc Parrou. He then carried out post-doctoral studies for 30 months at the Pasteur Institute under the direction of Dr. Carmen Buchrieser. In 2007 he took the position of INRA Research Associate (CR2: 2007-2011, CR1: 2011-present) in the laboratory of Microbiology and Molecular Genetics (AgroParisTech, Grignon) renamed in 2010, Micalis (UMR1319 - AgroParisTech). In 2013 he accepted a Consulting Professor position at AgroParisTech (department of Life Science and Health).

Dr. Jules worked on molecular physiology and carbon metabolism of lower eukaryotes with an accent on the metabolism of reserve carbohydrates. He further developed his expertise working on the crisscrossed regulations of virulence and metabolism in bacterial pathogens. Altogether, this led him to address several fundamental issues related to the overall functioning of a bacterial cell (metabolic network, cell adaptation, transcription and post-transcriptional regulations, translation, etc.).

Dr. Jules has published a total of 28 articles in peered reviews since 2004 (h-index 16).

Selection of 6 recent publications (the full list of publications can be found below):

* Equal contributors, $ Corresponding authors

  1. Guiziou S., Sauveplane V., Chang H.J., Clerté C., Declerck N., Jules M., Bonnet J. 2016. A part toolbox to tune genetic expression in Bacillus subtilisNucleic Acids Res. [Epub ahead of print]
  2. Borkowski O., Goelzer A., Schaffer M., Calabre M., Mäder U., Aymerich S., Jules M.$ and Fromion V. $. 2016. Translation elicits a growth-rate-dependent, genome-wide, differential protein production in Bacillus subtilis. Mol Syst Biol; 12:870.
  3. Chubukov V., Uhr M., Le Chat L., Kleijn RJ., Jules M., Link H., Aymerich S., Stelling J. and Sauer U. 2013. Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis. Mol Syst Biol; 9:709.
  4. Buescher J.M.*, Liebermeister W.*, Jules M.*, Uhr M.*, Muntel J.*, Botella E., Hessling B., Kleijn R.J., Le Chat L., Lecointe F., Mäder U., Nicolas P., Piersma S., Ruegheimer F., Becher D., Bessieres P., Bidnenko E., Denham E.L., Dervyn E., Devine K.M., Doherty G., Felicori L., Fogg M., Goelzer A., Hansen A., Harwood C.R., Hecker M., Hubner S., Hultschig C., Jarmer H., Klipp E., Leduc A., Lewis P., Molina F., Noirot P., Peres S., Piegeonneau N., Pohl S., Rasmussen S., Rinn B., Schaffer M., Schnidder J., Schwikowski B., van Dijl J.M., Veiga P., Walsh S., Wilkinson A.J., Stelling J., Aymerich S. and Sauer U. 2012. Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science;335(6072):1099-103.
  5. Nicolas P., Mäder U., Dervyn E., Rochat T., Leduc A., Pigeonneau N., Bidnenko E., Marchadier E., Hoebeke M., Aymerich S., Becher D., Bisicchia P., Botella E., Delumeau O., Doherty G., Denham E.L., Devine K.M., Fogg M., Fromion V., Goelzer A., Hansen A., Härtig E., Harwood C.R., Homuth G., Jarmer H., Jules M., Klipp E., Le Chat L., Lecointe F., Lewis P., Liebermeister W., March A., Mars R.A.T., Nannapaneni P., Noone D., Pohl S., Rinn B., Rügheimer F., Sappa P.K., Samson F., Schaffer M., Schwikowski B., Steil L., Stülke J., Wiegert T., Wilkinson A.J., van Dijl J.M., Hecker M., Völker U., Bessières P. and Noirot P. 2012. Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.Science;335(6072):1103-6.
  6. Ferguson M.L., Le Coq D., Jules M., Aymerich S., Radulescu o., Declerck N. and Royer C.A. 2011. Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states. Proc Natl Acad Sci USA; 109(1):155-60.
Matthieu Jules

Matthieu Jules

List of publications
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