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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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Tristan Rossignol

Tristan Rossignol
Researcher INRA

Tel: +33 (0)

Email: Tristan Rossignol

Since November 2010, Tristan Rossignol joined the BIMLip team lead by Jean-Marc Nicaud as a "Chargé de Recherches" at the MICALIS institute (INRA-AgroParisTech, UMR1319, Jouy-En-Josas) headed by Stéphane Aymerich. He is involved in metabolic engineering, integrative and system biology of the oleaginous yeast Yarrowia lipolytica with an emphasis on lipid metabolism, biolipids and enzymes production, and development of metabolic engineering tools.

He is actually workpackage leader in The european project H2020 CHASSY (Model-Based Construction and Optimisation of Versatile Chassis Yeast Strains for Production of Valuable Lipid and Aromatic Compounds).

Tristan Rossignol has a PhD in food sciences from Université Montpellier II (2004). He first spent 2 years as a post-doctoral fellow (2004-2006) at the University College Dublin (Irlande) in Butler's group, working on genomic of a pathogenic yeast. Then he joined the Unité Biologie et Pathogénicité Fongiques (INRA USC2019) leads by C. D'Enfert at Institut Pasteur (Paris, France) as a post-doctoral fellow for 4 years (2006-2010), working on new antifungal compounds and biofilm development of pathogenic yeasts.

List of recent publications (last 5 years)

1.           Soudier P, Larroude M, Celinska E, Rossignol T, Nicaud JM. 2019. Selection of Heterologous Protein-Producing Strains in Yarrowia lipolytica. Methods Mol Biol 1923:153-168.

2.           Park Y-K, Korpys P, Kubiak M, Celinska E, Soudier P, Trébulle P, Larroude M, Rossignol T, Nicaud J-M. 2019. Engineering the architecture of erythritol-inducible promoters for regulated and enhanced gene expression in Yarrowia lipolytica. FEMS Yeast Research 19:foy105-foy105.

3.           Larroude M, Park Y-K, Soudier P, Kubiak M, Nicaud J-M, Rossignol T. 2019. A modular Golden Gate toolkit for Yarrowia lipolytica synthetic biology. Microbial Biotechnology 0:1-11.

4.           Czerwiec Q, Idrissitaghki A, Imatoukene N, Nonus M, Thomasset B, Nicaud JM, Rossignol T. 2019. Optimization of cyclopropane fatty acids production in Yarrowia lipolytica. Yeast doi:10.1002/yea.3379.

5.           Beneyton T, Rossignol T. 2019. Droplet-based microfluidics high-throughput screening of enzyme mutant libraries secreted by Yarrowia lipolytica, Springer Protocols Handbooks (under press)

6.           Leplat C, Nicaud J-M, Rossignol T. 2018. Overexpression screen reveals transcription factors involved in lipid accumulation in Yarrowia lipolytica. FEMS Yeast Research 18:foy037-foy037.

7.           Legrand M, Bachellier-Bassi S, Lee KK, Chaudhari Y, Tournu H, Arbogast L, Boyer H, Chauvel M, Cabral V, Maufrais C, Nesseir A, Maslanka I, Permal E, Rossignol T, Walker LA, Zeidler U, Znaidi S, Schoeters F, Majgier C, Julien RA, Ma L, Tichit M, Bouchier C, Dijck PV, Munro CA, d’Enfert C. 2018. Generating genomic platforms to study Candida albicans pathogenesis. Nucleic Acids Research 46:6935-6949.

8.           Larroude M, Rossignol T, Nicaud JM, Ledesma-Amaro R. 2018. Synthetic biology tools for engineering Yarrowia lipolytica. Biotechnol Adv 36:2150-2164.

9.           Lazar Z, Neuvéglise C, Rossignol T, Devillers H, Morin N, Robak M, Nicaud J-M, Crutz-Le Coq A-M. 2017. Characterization of hexose transporters in Yarrowia lipolytica reveals new groups of Sugar Porters involved in yeast growth. Fungal Genetics and Biology 100:1-12.

10.         Celinska E, Ledesma-Amaro R, Larroude M, Rossignol T, Pauthenier C, Nicaud JM. 2017. Golden Gate Assembly system dedicated to complex pathway manipulation in Yarrowia lipolytica. Microb Biotechnol 10:450-455.

11.         Beneyton T, Thomas S, Griffiths AD, Nicaud J-M, Drevelle A, Rossignol T. 2017. Droplet-based microfluidic high-throughput screening of heterologous enzymes secreted by the yeast Yarrowia lipolytica. Microbial Cell Factories 16:18.

12.         Gajdoš P, Ledesma-Amaro R, Nicaud J-M, Čertík M, Rossignol T. 2016. Overexpression of diacylglycerol acyltransferase in Yarrowia lipolytica affects lipid body size, number and distribution. FEMS Yeast Research 16:fow062.

13.         Back A, Rossignol T, Krier F, Nicaud J-M, Dhulster P. 2016. High-throughput fermentation screening for the yeast Yarrowia lipolytica with real-time monitoring of biomass and lipid production. Microbial Cell Factories 15:147.

14.         rakicka M, lazar Z, neuvéglise C, Rossignol T, Nicaud J-M, Robak M. 2015. Produkcja kwasu cytrynowego z melasy z wykorzystaniem transformantów Yarrowia lipolytica INZYNIERIA I APARATURA CHEMICZNA 54:111-113.

15.         Leplat C, Nicaud JM, Rossignol T. 2015. High-throughput transformation method for Yarrowia lipolytica mutant library screening. FEMS Yeast Res 15:fov052.

16.         Gajdos P, Nicaud JM, Rossignol T, Certik M. 2015. Single cell oil production on molasses by Yarrowia lipolytica strains overexpressing DGA2 in multicopy. Appl Microbiol Biotechnol 99:8065-8074.

17.         Morin N, Crutz-Le Coq A-M, Rossignol T, Nicaud J-M. 2014. Protocols for Monitoring Growth and Lipid Accumulation in Oleaginous Yeasts, p 1-17. In McGenity TJ (ed), Hydrocarbon and Lipid Microbiology Protocols doi:10.1007/8623_2014_40. Humana Press.

18.         Janbon G, Ormerod KL, Paulet D, Byrnes EJ, 3rd, Yadav V, Chatterjee G, Mullapudi N, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EW, Coppee JY, Floyd-Averette A, Gaillardin C, Gerik KJ, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh YP, Ianiri G, Jones S, Kodira CD, Kozubowski L, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wollschlaeger C, Wood IA, Zeng Q, Neuveglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J, Fraser JA, et al. 2014. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet 10:e1004261.

19.         Cabral V, Znaidi S, Walker LA, Martin-Yken H, Dague E, Legrand M, Lee K, Chauvel M, Firon A, Rossignol T, Richard ML, Munro CA, Bachellier-Bassi S, d'Enfert C. 2014. Targeted changes of the cell wall proteome influence Candida albicans ability to form single- and multi-strain biofilms. PLoS Pathog 10:e1004542.

20.         Znaidi S, Nesseir A, Chauvel M, Rossignol T, d'Enfert C. 2013. A Comprehensive Functional Portrait of Two Heat Shock Factor-Type Transcriptional Regulators Involved in Candida albicans Morphogenesis and Virulence. PLoS Pathog 9:e1003519.

21.         Rossignol T, Kocsis B, Bouquet O, Kustos I, Kilar F, Nyul A, Jakus PB, Rajbhandari K, Prokai L, d'Enfert C, Lorand T. 2013. Antifungal Activity of Fused Mannich Ketones Triggers an Oxidative Stress Response and Is Cap1-Dependent in Candida albicans. PLoS ONE 8:e62142.

22.         Lazar Z, Rossignol T, Verbeke J, Crutz-Le Coq A-M, Nicaud J-M, Robak Mg. 2013. Optimized invertase expression and secretion cassette for improving Yarrowia lipolytica growth on sucrose for industrial applications. Journal of Industrial Microbiology & Biotechnology 40:1273-1283.