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Seav-ly Tran, PhD

I am a research scientist extensive experience in microbiology and host-pathogen interactions.

During my thesis, I investigated Bacillus cereus virulence and mechanisms to escape the host immune response. After I graduated in 2010, I joined Dr Deborah Foster research group (Ryerson University, Toronto, Canada) where I studied the impact of gastro-intestinal stress conditions induced by human on Shiga toxin producing E. coli (STEC) virulence. I also gained expertise on the subject of antimicrobial agents through testing the antimicrobial activity of a new synthetic peptide. I continued my work on STEC by looking at Shiga toxin translocation across the gut using a microaerobic vertical diffusion chamber system that mimics the gut low oxygen environment. This piece of work was done in Stephanie Schüller research group (UEA-Quadram Institute, UK)

I am currently the project manager of the PIMS team project “Therapeutic innovation: new antibiotic strategy”. I have been leading this project since 2017. Using a structure-based approach, we aim to identify drugs with an innovative mechanism of action. I was also the grant holder of the Initiative d’excellence Paris Saclay, NewMed2.0, new antimicrobials (2018-2019, 80k€) funding.

My other projects also focused on applied research and innovation, and concentrate around technologies associated with food safety.

ORCID 0000-0001-7014-6601

Education

Jan 2010: PhD, Microbiology, Agro Paris Tech, France

2006: MSc, Molecular and Cellular Biology, Sorbonne University, France

2004: BSc, Biochemistry, UNIMES University, France

Current position: Sept 2016 to date, Research scientist, Micalis unit, INRAe, France

Previous employment:

2015-2016: Research Associate, Department of Pathology, University of Cambridge, UK- D. Humphreys group

2012-2015: Research Associate, Medical School, University of East Anglia, UK, Quadram Institute, UK- S. Schüller group

2010-2011: Post-doctoral position, Department of Chemistry and Biology-Ryerson University, Canada- D. Foster group

Publications

20 publications in peer reviewed journals, 1 patent

Guest editor

https://www.mdpi.com/journal/pathogens/special_issues/Host_Pathogen_Interactions

5 major papers in the last 5 years

1- Tran SL, Cormontagne D, Vidic J, André-Leroux G, Ramarao N. Structural Modeling of Cell Wall Peptidase CwpFM (EntFM) Reveals Distinct Intrinsically Disordered Extensions Specific to Pathogenic Bacillus cereus Strains. Toxins (Basel). 2020 Sep 14;12(9):E593. doi: 10.3390/toxins12090593

2-Ramarao N, Tran SL, Marin M, Vidic J. Advanced Methods for Detection of Bacillus cereus and Its Pathogenic Factors. Sensors (Basel). 2020 May 7;20(9):2667. doi: 10.3390/s20092667.

3- Porrini C, Ramarao N, Tran SL. Dr. NO and Mr. Toxic - the versatile role of nitric oxide. Biol Chem. 2020 Apr 28;401(5):547-572. doi: 10.1515/hsz-2019-0368.

4-Tran SL, Jenkins C, Livrelli V, Schüller S. Shiga toxin 2 translocation across intestinal epithelium is linked to virulence of Shiga toxin-producing Escherichia coli in humans. Microbiology (Reading). 2018 Apr;164(4):509-516. doi: 10.1099/mic.0.000645

5- Guillemet E, Leréec A, Tran SL, Royer C, Barbosa I, Sansonetti P, Lereclus D, Ramarao N. The bacterial DNA repair protein Mfd confers resistance to the host nitrogen immune response. Sci Rep. 2016 Jul 20;6:29349. doi: 10.1038/srep29349

Awards and Grants

2018: Initiative d’excellence Paris Saclay, NewMed2.0, new antimicrobials (2018-2019)

2016: Prestige fellowship (2016-2018, Marie Curie Fellowship)

2009: Student Travel Awards from ASM Conferences for Bacillus-ACT 2009

2006: PhD scholarship from the French Research and Education Ministry

Cover page

Toxins, Volume 12, Issue 9, September 2020