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In RCL lab I am analyzing actin homologue MreB from Bacillus subtilis, to study its dynamics and biophysical properties by using TIRF live imaging of in vitro isolated MreB.

McDougall A, Hebras C, Pruliere G, Burgess D, Costache V, Dumollard R, Chenevert Janet. (2017) Role of midbody remnant in meiosis II creating tethered polar bodies. BioRxiv (doi: https://doi.org/10.1101/191981);

Costache V, Hebras C, Pruliere G, Besnardeau L, Failla M, Copley R, Burgess D, Chenevert J*, McDougall A*. (2017) Kif2 localizes to a subdomain of cortical endoplasmic reticulum that drives asymmetric spindle position. Nature Communications 8(1):917.;

Chassé H§, Boulben S§, Costache V, Cormier P, Morales J*. (2017) Analysis of translation using polysome profiling. Nucleic Acid Research. 45(3):e15. [Epub Oct 2016];

McDougall A, Chenevert J, Pruliere G, Costache V, Hebras C, Salez G and Dumollard R. (2015). Centrosomes and spindles in ascidian embryos and eggs. Methods in Cell Biology, Centrosome & Centriole (129) 317-39;

Costache V, McDougall A, Dumollard R. (2014) Cell cycle arrest and activation of development in marine invertebrate deuterostomes, Biochem Biophys Res Commun. Aug 1;450(3):1175-81;

Costache V, Bilotto S, Laguerre L, Bellé R, Cosson B, Cormier P and Morales J. (2012). Dephosphorylation of eIF2alpha is essential for protein synthesis increase and cell cycle progression after sea urchin fertilization. Developmental Biology May 1;365(1):303-9;

Musnier A, Leon K, Morales J, Reiter E, Boulo T, Costache V, Vourc'h P, Heitzler D, Oulhen N, Poupon A, Boulben S, Cormier P, Crepieux P. (2012). mRNA-Selective Translation Induced by FSH in Primary Sertoli Cells. Molecular Endocrinology Apr;26(4):669-80;

Personal description

I am a cell biologist specialized in micromanipulations and in vivo imaging of cells and embryos. I’m interested in cytoskeleton organization, functions and dynamics, on both microtubules and actin. I worked on eukaryotic model systems until now and I am looking forward to discover new things using prokaryotes.

CV

Jan 2017 – Jan 2019 | CDD Research Associate INSERM – "Imaging Cortical Actomyosin and Cell dynamics in vivo using single-molecule technics."

François Robin Lab / Laboratoire Biologie du Développement, IBPS, ERL1156, UMR 7622, CNRS, Sorbonne Université, Paris

March 2013 – March 2016 | CDD Research Assistant CNRS – "Imaging asymmetric cell divisions in live ascidian embryos."

Alex McDougall Lab / Developmental Biology Unit UMR7009, Institut de la Mer de Villefranche, Sorbonne Université, CNRS, Villefranche-sur-Mer.

2008 – 2011 | PhD Degree in Cell Biology and Biochemistry. "Translational Control of mRNAs during early embryogenesis of the sea urchin".

Advisor: Julia Morales DR2 CNRS, in Patrick Cormier Lab (UMR 7150), “Station Biologique de Roscoff” Univ Paris 6/ CNRS and Univ Rennes1.  Roscoff

2007 – 2008 |Master of Science Degree, Marine Biology Sciences. The European Institute for Marine Studies (IUEM), Université de Bretagne Occidentale (UBO), Brest.

2006 | Bachelor of Science Degree, Biology and Natural Sciences at "Ovidius" University, Constanta, Romania.

Other activities

I am a scientific diver (INPP) Classe 1 - mention B (2013), and I love to climb, to ride motorcycles and bicycles, and to listen to good Rock’n Roll music and blues :-)