Amandine Paulay

Amandine Paulay

PhD student (February 2020 - January 2021)

2nd year of Master trainee (January – July 2019)
Research engineer (August 2019 – January 2020)

After graduating from a Master of Science in Genomics and Environment at Université Paris-Saclay, I am currently in my first year of PhD, co-financed by Biomathematica and an ARNT scholarship at ABIES doctoral school. This study is at the interface of microbiology, bioinformatics and mathematical models. The main theme of this PhD is the degradation of dietary proteins by the human gut microbiota. This project comprises two complementary aspects, one at the bacteria scale and another one at a community scale. The first part consists in modelling protein degradation by a stain of Bacteroides caccae, by analysis its metabolism using a flux balance analysis model. The second aspect consists in studying the distribution of proteases’ genes expression in the human gut microbiota using nonnegative matrix factorisation to identify specific expression patterns under different conditions (diseases, diet).

Modification date : 14 September 2023 | Publication date : 29 November 2018 | Redactor : PhylHom