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My thesis focused on an important biological question : understanding the function of a group of hubs discovered in Bacillus subtilis. These hubs are located at the interface of several essential cellular processes such as DNA replication, cell division, chromosome segregation, stress response and biogenesis of the bacterial cell wall. Different systematic approaches were combined : transcriptome data, genes context, protein localization, interactome analysis… The integration of these data allowed to clarify the functional context of the genes of interest and to make assumptions about the nature of interactions between hub proteins. The group of hubs appears finally composed of a few groups of co-expressed proteins (party hubs) which can interact together and other proteins expressed in an uncorrelated manner (date hubs).

Monteferrante CG, MacKichan C, Marchadier E, Prejean MV, Carballido-López R, van Dijl JM. Mapping the twin-arginine protein translocation network of Bacillus subtilis. Proteomics. 2013 Mar;

Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P. Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science. 2012 Mar;

Marchadier E, Carballido-López R, Brinster S, Fabret C, Mervelet P, Bessières P, Noirot-Gros MF, Fromion V, Noirot P. An expanded protein-protein interaction network in Bacillus subtilis reveals a group of hubs: Exploration by an integrative approach. Proteomics. 2011 Aug;