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• (01.11.2021-) PhD Thesis subject: Resistance to the last-resort antibiotic colistin in Pseudomonas aeruginosa. Development of multidrug-resistant (MDR) bacterial strains pose a major clinical challenge to infection treatment worldwide. Polymixin E (colistin), carbapenems, and tigecycline alone or in combination therapy have become the last-resort antibiotics for treating infections caused by MDR bacteria. However, resistance to these reserve antibiotics too is increasingly being reported worldwide. Among these therapies, an emerging approach is to find other agents that will synergistically restore the efficacy of these antibiotics. The aim of the project is to combine ground-breaking fluorescence microscopy techniques with genetic and cell biology approaches to investigate the mechanisms underlying the synergistic antibacterial activity of a recently approved CF drug in combination with colistin in the Gram-negative pathogen P. aeruginosa.
• (06.01.2021 – 06.07.2021) M2 internship subject: Super-Resolution Microscopy Approaches to Elucidate the Ultrastructure of Actin-like MreB Assemblies in Bacillus subtilis. The rod-shaped model bacterium Bacillus subtilis was used to understand the ultrastructure and dynamics of structures formed by the bacterial actin-like protein MreB by using two super resolution microscopy techniques: lattice-SIM and PALM. MreB is an essential protein that controls cell width and helps to maintain the cell shape in B. subtilis. It is highly dynamic, moving along the short axis of cells. The size in length of MreB filamentous assemblies was previously revealed by using SIM-TIRF microscopy. However, their ultrastructure in vivo, and in particular the width of MreB assemblies remain unclear because it is below the resolution limit of SIM (~100 nm lateral resolution). In the project, lattice-SIM and PALM imaging were done to investigate the ultrastructure of MreB assemblies.

2020-2021: Fundamental Microbiology Master Degree, Paris Saclay University, Graduate School Life Sciences & Health, Paris, FRANCE

2015-2020: Molecular Biology and Genetics (100% English) Bachelor Degree, Canakkale Onsekiz Mart University, Faculty of Arts and Sciences, Canakkale, TURKEY