Microbiology laboratories are making little use of continuous culture systems in bioreactors despite their interest. In order to facilitate their implementation, this thesis project aims to develop a new modular system of computer-controlled mini-bioreactors taking advantage of the opportunities offered by the development of digital fabrication and programmable microcontrollers. The target culture volumes are thought to be in the range of 5 to 10 mL to allow complex experimental designs involving numerous bioreactors (in parallel, in series, with in real time monitoring and control, …). Several applications were performed, mainly with the Gram-positive bacteria Bacillus subtilis, to validate and illustrate the use of the proposed system. These will encompass experimental and directed evolution set-ups.