Antibiotic resistance: towards drugs to disarm bacteria

A new strategy to combat antibiotic resistance

A consortium of researchers with multidisciplinary skills, coordinated by INRAE and including the CNRS, the Université Paris-Saclay and Inserm, has identified a molecule capable of “disarming” pathogenic bacteria in the face of the immune system, without any negative effects on the host microbiota. These results, already patented and recently published in Nature Communications, are leading to the development of new drugs.

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Nalini RAMA RAO

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Tran*, L. Lebreuilly*, D. Cormontagne*, S. Samson, TB. Tô, M. Stosskopf, R. Dervyn, A. Grießhammer, J. de la Cuesta-Zuluaga, L. Maier, T. Naas, S. Mura, D. Rognan, J. Nicolas, G. André and N. Ramarao*. An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens. Nat Commun. 2025 Apr 28;16(1):3324. doi: 10.1038/s41467-025-58282-8

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