A new mechanism for inhibiting bacterial division

Structured Illumination Microscopy of ComM, PBP2x, RodA and DivIV molecule machineries implied during division ring in S. pneumoniae

Natural genetic transformation is integrated into the cell cycle of pneumococcus. The pathogenic bacterium S. pneumoniae, commonly known as pneumococcus, is capable of integrating DNA sequences present in the external environment into its genome. This natural transformation process, which is highly conserved in bacteria, contributes to their diversification by enabling intra- and inter-species gene exchange. […]

Extracellular DNA filaments associated with surface polysaccharide II give Clostridioides difficile biofilm matrix a network-like structure

Clostridioides difficile is a Gram-positive, strictly anaerobic, spore-forming bacterium responsible for nosocomial and community-acquired intestinal infections. One of the major problems associated with these infections is the frequent occurrence of recurrences: in 15 to 25% of cases after a first episode, often due to a relapse linked to the same bacterial strain. These relapses are […]

Identify and use key bacteria from the intestinal microbiota to promote its ecological barrier effect against antibiotic-resistant pathogenic bacteria

The gastrointestinal tract is a reservoir of opportunistic pathogens, where pathobionts take advantage of dysbiosis to proliferate in immunocompromised patients. Vancomycin-resistant enterococci (VRE) originate from the gastrointestinal tract, where their proliferation precedes dissemination into the bloodstream and can lead to systemic infection. Understanding the mechanisms responsible for resistance to intestinal colonisation by VRE is essential […]

Antibiotic resistance: towards drugs to disarm bacteria

A new strategy to combat antibiotic resistance A consortium of researchers with multidisciplinary skills, coordinated by INRAE and including the CNRS, the Université Paris-Saclay and Inserm, has identified a molecule capable of “disarming” pathogenic bacteria in the face of the immune system, without any negative effects on the host microbiota. These results, already patented and […]

Luca Ciandrini- 19/06/2025

The growth-laws cookbook: Ingredients and recipes for mechanistic models of ribosome allocation in bacteria and beyond

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