Zeynep Baharoglu – 13/02/2025
Epitranscriptomic response to antibiotics in Vibrio cholerae
Phage-mediated intercellular CRISPRi for biocomputation in bacterial consortia
In the field of Synthetic Biology, biological systems are engineered to sense inputs and respond in a programmed manner, a process called biological computing. Traditional biocomputing faces limitations due to the resource burden on single engineered cells, restricting the amount of foreign DNA they can simultaneously express. A recent solution, distributed biological computing, involves using […]
The 2024 MICALIS symposium
Our annual symposium took place on Friday, December 6, 2024. It was a great success! Philippe Langella, INRAE laureate, opened the day with a talk on the history of Faecalibacterium prausnitzii. Six major new French and European collaborative projects were then presented in the morning. In the afternoon, we had the chance to discover […]
Lydia Palaiodimou – 17/12/2024
Molecular Insights into L. monocytogenes Persistence via Label-Free Quantitative Proteomics
Camille Dop – 19/12/2024
Mechanisms of microbiome adaptation to chronic exposure to xenobiotics and its impact on secondary treatment responses
Nathalie Laforge – 18/12/2024
Construction and directed evolution of mutualistic synthetic consortia of Bacillus subtilis
Claire-Jing Rouchet – 27/11/2024
The effect of membrane fluidity on cell wall shape and elongation in Bacillus subtilis
Anaïs Lemaire – 10/12/2024
Caractérisation des biofilms in vitro et évaluation de la diversité génomique et de la transmission de Clostridioides difficile
Raphaël Charron – 25/11/2024
Impact of bacterial biofilm adaptation to biocides on antibiotic resistance
FabT, a Streptococcus pyogenes membrane lipid regulator that flips the switch between bacterial sur-vival and virulence
The pathogen Streptococcus pyogenes (Group A Streptococcus; GAS) causes severe infections with long-term sequellae. GAS infections account for 517,000 deaths annually worldwide. The research teams at the Cochin Institute (Bactéries et périnatalité; INSERM and CNRS) and at Micalis Institute (MicrobAdapt, INRAE) were intrigued by the presence of variants that emerged during experimental infections in primates, […]