B3D
Biofilms and Spatially Organized Communities Welcome to the B3D team! Committed to unravelling the complex world of microbiology in the food chain, our primary focus is on understanding and mitigating the hazards posed by pathogens in the context of spatially organised microbial communities present in biofilms and food matrices. Our comprehensive approach aims to develop […]
BaPS
Pathogenic Bacteria and Health Our team is working on the pathophysiology of Clostridioides difficile infections, an anaerobic, spore-forming Gram-positive bacterium that is a major enteropathogen in human and animal health. C. difficile has been classified as an urgent threat in terms of antibiotic resistance by the CDC in 2019 (Centers for Disease Control and Prevention […]
ComBac
Bacterial Communication The team « Communication Bactérienne » (ComBac) conducts fundamental and applied researches on lactic acid bacteria, especially Streptococcus and Lactococcus. We are interested in understanding their adaptative responses to their various ecosystems including food matrices, intestinal microbiota and host, and how these responses impact their environment using different approaches (microbiology, genetics, biochemistry, genomics and post-genomics, […]
CPE
Commensalism and Pathogenesis of Enterococci Fight against pathogenic and multi-resistant bacteria is a major challenge for human and animal health. The gastrointestinal tract is a reservoir for opportunistic pathogens or pathobionts, which benefit from the imbalance or dysbiosis of the microbiota to invade and infect susceptible hosts. Enterococci, especially Enterococcus faecalis and Enterococcus faecium, rank […]
DynPhages
Bacteriophage Genome Dynamics Bacteriophages have been evolving on Earth for billions of years, and are found everywhere. The Bacteriophage genome dynamics team (DynPhage) wants to decipher molecular mechanisms at the root of their ecological success, and to evolve them as potent alternatives to antibiotics against pathogens such as Enterococcus faecium, Escherichia coli and Pseudomonas aeruginosa. […]
GME
Microbial Genetics and Environment The GME team studies the pathogenic and adaptive properties of the spore-forming bacteria of the Bacillus cereus sensu lato group, as well as Clostridioides difficile. To reach our objectives we rely on molecular genetics and biochemistry approaches combined with single-cell imaging technologies and the use of the versatile infection model Galleria mellonella. As […]
MicrobAdapt
Determinants of Microbial Adaptation Major pathogens Staphylococcus aureus, Streptococcus agalactiae, and Campylobacter can all colonize and infect humans and livestock. These species also contaminate food matrices, which can be reservoirs of host infection. Antibiotic resistance increases the risks of treatment failure. Our goals are to: Limit infection by understanding the role of bacterial interactions on […]
Paroi
Bacterial cell wall dynamics Gram-positive bacteria are encased in a thick cell wall consisting of a complex and dynamic assembly of several glycopolymers (peptidoglycan, polysaccharides, teichoic acids) and proteins. It is a rigid structure to maintain cell shape and integrity but also a flexible one to accommodate cell growth and division and to face changing […]
PIMs
Pathogens, Immunity and Microbiota The PIMs team is expert in the study of bacterial resistance to the host immune system. We characterize the effects of the immune response on pathogenic bacteria and develop new strategies of anti-virulence to combat bacterial infections. Our team develops innovative strategies to combat bacterial infections based on our knowledge and […]
EpiMiC
Epigenetics and Cellular Microbiology Our team studies the long-term impact of pathogenic bacteria on health. In particular, we are interested in understanding the molecular basis of persistent bacterial infections and determine mechanistic details underlying bacterial dormancy. We use the facultative intracellular pathogen Listeria monocytogenes as a bacterial model to tackle these questions. In the long […]