Antibiotic resistance: towards drugs to disarm bacteria
A new strategy to combat antibiotic resistance A consortium of researchers with multidisciplinary skills, coordinated by INRAE and including the CNRS, the Université Paris-Saclay and Inserm, has identified a molecule capable of “disarming” pathogenic bacteria in the face of the immune system, without any negative effects on the host microbiota. These results, already patented and […]
Jun Ogawa – 05/05/2025
Analysis of microbial function creating novel biotechnology tools for food, medical, and chemical industries
Identification of Gut Biomarkers of FPIES (Food protein induced enterocolitis syndrome) in a Longitudinal Comparative Pediatric Study
Anais Lemoine, a paediatrician at APHP’s Trousseau hospital, did her PhD at Micalis, in the Probihôte team. This study is the result of collaboration with clinicians from the APHP at Trousseau and Pitié-Salpétrière hospitals and two INRAE laboratories at UPSaclay (Micalis and MTS/LIAA). Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy without known biomarkers. […]
Phage-mediated intercellular CRISPRi for biocomputation in bacterial consortia
In the field of Synthetic Biology, biological systems are engineered to sense inputs and respond in a programmed manner, a process called biological computing. Traditional biocomputing faces limitations due to the resource burden on single engineered cells, restricting the amount of foreign DNA they can simultaneously express. A recent solution, distributed biological computing, involves using […]
Raphaël Charron – 25/11/2024
Impact of bacterial biofilm adaptation to biocides on antibiotic resistance
FabT, a Streptococcus pyogenes membrane lipid regulator that flips the switch between bacterial sur-vival and virulence
The pathogen Streptococcus pyogenes (Group A Streptococcus; GAS) causes severe infections with long-term sequellae. GAS infections account for 517,000 deaths annually worldwide. The research teams at the Cochin Institute (Bactéries et périnatalité; INSERM and CNRS) and at Micalis Institute (MicrobAdapt, INRAE) were intrigued by the presence of variants that emerged during experimental infections in primates, […]
Aquatic environment drives the emergence of cell wall-deficient dormant forms in Listeria
Bacteria can respond to environmental stresses by entering a dormant state called viable but non-culturable (VBNC) state. VBNC bacteria lose the ability to grow in routine culture media. Pathogens entering a VBNC state pose a significantly risk for human and animal health, as they are not detected by standard growth-based techniques, and can “wake up” […]
B3D and Lallemand Animal Nutrition launch LabCom “Biofilm1Health”
From livestock buildings to the International Space Station, and even in our toothbrushes, biofilms, composed of three-dimensional microbial communities, have colonized the environment since time immemorial. For over twenty years, the INRAE B3D team – Biofilms and Spatially Organized Communities – at the Micalis Joint Research Unit has been deciphering the functioning of these microscopic […]
COST Action “Building Consensus on Biofilm Regulatory Decision Making” (CA23152)
The B3D team is thrilled to participate in a new COST Action, officially launched in Brussels on September 26th. This initiative brings together a network of international biofilm experts from diverse academic fields. Its primary goal is to bridge the gap between academic research, industrial applications, and regulatory frameworks by establishing unified guidelines for biofilm-related […]
Biofilms: Microbes in Society
From livestock buildings to the International Space Station, and even in our toothbrushes, biofilms, composed of three-dimensional microbial communities, have colonized the environment since time immemorial. For over twenty years, the INRAE B3D team – Biofilms and Spatially Organized Communities – at the Micalis Joint Research Unit has been deciphering the functioning of these microscopic […]