Biofilms en mouvement – nouvelles frontières, nouveaux défis
11e colloque du Réseau National Biofilms
Spatial growth of major foodborne pathogens in food-like matrices alters food-related stress responses and gastrointestinal tolerance
How does the spatial organisation of foodborne pathogens influence their stress tolerance and survival? Happy to share our latest publication in npj Science of Food. During her PhD jointly conducted between AERIAL and the Micalis Institute, Elodie Hoch investigated how growth as 3D microcolonies within food-like matrices shapes the physiology of major foodborne pathogens. Our […]
FIGHTING ANTIMLICROBIAL RESISTANCE IN THE AGE OF ARTIFICIAL INTELLIGENCE
Human Microbiome: From Models and Mechanism to Medicine
Scientific illustration as a multiscale framework for representing biofilms
This paper started with an encounter between microbiology and scientific illustration. Two years ago, Antoine Carlioz, then a student at École Estienne in Paris, joined us for his final degree project with a challenge: How can we visually represent the complexity of biofilms across scales? That collaboration grew into a much larger project, and I […]
3D imaging and artificial intelligence: a dual breakthrough to design protective biofilms against harmful bacteria
By combining 3D imaging and artificial intelligence, two recent scientific publications have opened a new path to design protective biofilms. These microbial communities, when properly assembled, can block pathogens such as Salmonella. This innovative experimental and predictive approach reduces reliance on antibiotics and biocides, with promising applications for animal health, food safety, and environmental protection.Bacteria […]
Extracellular DNA filaments associated with surface polysaccharide II give Clostridioides difficile biofilm matrix a network-like structure
Clostridioides difficile is a Gram-positive, strictly anaerobic, spore-forming bacterium responsible for nosocomial and community-acquired intestinal infections. One of the major problems associated with these infections is the frequent occurrence of recurrences: in 15 to 25% of cases after a first episode, often due to a relapse linked to the same bacterial strain. These relapses are […]
Identify and use key bacteria from the intestinal microbiota to promote its ecological barrier effect against antibiotic-resistant pathogenic bacteria
The gastrointestinal tract is a reservoir of opportunistic pathogens, where pathobionts take advantage of dysbiosis to proliferate in immunocompromised patients. Vancomycin-resistant enterococci (VRE) originate from the gastrointestinal tract, where their proliferation precedes dissemination into the bloodstream and can lead to systemic infection. Understanding the mechanisms responsible for resistance to intestinal colonisation by VRE is essential […]
Antibiotic resistance: towards drugs to disarm bacteria
A new strategy to combat antibiotic resistance A consortium of researchers with multidisciplinary skills, coordinated by INRAE and including the CNRS, the Université Paris-Saclay and Inserm, has identified a molecule capable of “disarming” pathogenic bacteria in the face of the immune system, without any negative effects on the host microbiota. These results, already patented and […]
Jun Ogawa – 05/05/2025
Analysis of microbial function creating novel biotechnology tools for food, medical, and chemical industries
Identification of Gut Biomarkers of FPIES (Food protein induced enterocolitis syndrome) in a Longitudinal Comparative Pediatric Study
Anais Lemoine, a paediatrician at APHP’s Trousseau hospital, did her PhD at Micalis, in the Probihôte team. This study is the result of collaboration with clinicians from the APHP at Trousseau and Pitié-Salpétrière hospitals and two INRAE laboratories at UPSaclay (Micalis and MTS/LIAA). Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy without known biomarkers. […]